Dichlorophenyl-ABA NEW
| Price | $653 | $926 | $1230 |
| Package | 25mg | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-23 |
Product Details
| Product Name: Dichlorophenyl-ABA | CAS No.: 18201-65-5 |
| Purity: 99.86% | Supply Ability: 10g |
| Release date: 2026/04/23 |
Product Introduction
Bioactivity
| Name | Dichlorophenyl-ABA |
| Description | Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor that effectively suppresses pathological protein aggregation, inhibiting more than 80% of aggregate formation in TTR L55P-expressing cells, Dichlorophenyl-ABA is widely employed in amyloidosis research to study TTR stabilization, aggregation mechanisms, and therapeutic intervention strategies. |
| In vitro | Dichlorophenyl-ABA can prevent L55P aggregate formation in the conditioned medium. Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP). However, it needs to undergo further stages of drug development to overcome its toxicity. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (283.57 mM), Sonication is recommended. |
| Keywords | Transthyretin (TTR) amyloid fibril formation | Dichlorophenyl-ABA | DichlorophenylABA | Dichlorophenyl ABA |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
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TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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