Product Details
| Product Name:
Diflapolin |
CAS No.:
724453-98-9 |
| Purity:
99.97% |
Supply Ability:
10g |
| Release date:
2026/08/03 |
Product Introduction
Bioactivity
| Name | Diflapolin |
| Description | Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP) and soluble epoxide hydrolase (sEH) inhibitor, exhibiting marked anti-inflammatory efficacy and high target selectivity. |
| In vitro | Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC50s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC50=20?nM). |
| In vivo | Diflapolin (1-10 mg/kg; i.p.; 30 min before zymosan injection) demonstrates potent anti-inflammatory properties in in-vivo experiments. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Corn Oil : 3.3 mg/mL (7.2 mM), Sonication is recommended.
DMSO : 84 mg/mL (183.26 mM), Sonication is recommended.
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| Keywords | vascular | sHE | permeability | neutrophil | Inhibitor | inhibit | inflammation | infiltration | FLAP | EpoxideHydrolase | Epoxide Hydrolase | diseases | Diflapolin | cysteinyl-LTs | 5-LO activating protein |
| Inhibitors Related | 1,3-Diphenylurea | Valpromide | VU534 | PAL-4 | N,N'-Dicyclohexylurea | (Rac)-EC5026 | CAY10640 | sEH inhibitor-3 | GSK2256294A | Dual FAAH/sEH-IN-1 | FEN1-IN-1 | FEN1-IN-3 |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compound Library Plus | Multi-Target Compound Library | Inhibitor Library | NO PAINS Compound Library | Lipid Metabolism Compound Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States