DLin-KC2-DMA NEW
| Price | $76 | $123 | $248 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: DLin-KC2-DMA | CAS No.: 1190197-97-7 |
| Purity: 98.60% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | DLin-KC2-DMA |
| Description | DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing. |
| In vitro | METHODS: Macrophages (MΦ) and dendritic cells (DC) were treated with DLinKC2-DMA (1,5μg/mL) to observe the effect of DLinKC2-DMA on siRNA-mediated gene silencing. GAPDH and control α-tubulin expression were evaluated using Western blot analysis and flow cytometry. RESULTS At a dose level of 5μg/ml, LNPs containing DLinKC2-DMA were again the most effective gene silencing agents. [1] |
| In vivo | METHODS: C57Bl6 mice were injected with DLinKC2-DMA-formulated LNP siRNA (5 mg/kg, tail vein injection) via the tail vein to study the in vivo gene silencing properties of DLinKC2-DMA-formulated LNP siRNA. RESULTS DLinKC2-DMA effectively silenced target genes in APcs in vivo. [1] |
| Storage | Store at low temperature Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 50 mg/mL (77.87 mM), Sonication is recommended. DMSO : 250 mg/mL (389.35 mM), Sonication is recommended. 10% DMSO+90% Saline : 10 mg/mL (15.57 mM), Solution. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (6.23 mM), Sonication is recommended. |
| Keywords | Inhibitor | inhibit | DLin-KC2-DMA | DLin-KC-2-DMA | DLinKC2DMA | DLin KC2 DMA |
| Inhibitors Related | Stearamide | DOPE | DOTAP chloride | Dimethyldioctadecylammonium (bromide) | DMG-PEG 2000 | 1,2-Distearoyl-sn-glycero-3-phosphorylcholine | DODAP | D-Lin-MC3-DMA | Benzyl nicotinate | 1,2-Dierucoyl-sn-glycero-3-PC | Cholesterol | Phosphatidylcholines,soya |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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