Product Details
| Product Name:
DMHCA |
CAS No.:
79066-03-8 |
| Purity:
99.47% |
Supply Ability:
10g |
| Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | DMHCA |
| Description | DMHCA is a selective LXR agonist with anti-inflammatory activity, which induces ABCA1 expression and upregulates FASN and SREBP-1alpha gene expression. |
| In vitro | Treatment of diabetic CD34+ cells with 10 μM DMHCA restored cell membrane fluidity to non-diabetic baseline levels. DMHCA restored bone marrow-derived TNF-α and IL-3 levels to baseline and significantly reduced CCL-2 production in bone marrow supernatant and systemic circulation. In addition, DMHCA increased the number of circulating vascular progenitor cells (CACs) in the bone marrow and peripheral circulation and facilitated the migration of vascular repair cells into the peripheral circulation. [1] |
| In vivo | DMHCA was able to restore cholesterol homeostasis in the diabetic retina by oral administration of 8 mg/kg/day for 6 months. In diabetic retina, DMHCA significantly increased the levels of endogenous LXR ligand, norethisterol and total oxidized sterols. [1] |
| Storage | Store at -20°C
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5 mg/mL (12.45 mM), Sonication is recommended.
|
| Keywords | LXR | LiverXReceptor | Liver X Receptor | DMHCA |
| Inhibitors Related | SR 1903 | GW6340 | T0901317 | Taraxasterol | SR9238 | BMS-779788 | SBI-477 | BE1218 | IMB-808 | Saikosaponin A | GW3965 hydrochloride | Rovazolac |
| Related Compound Libraries | Nuclear Receptor Compound Library | Bioactive Compound Library | Lipid Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Transcription Factor-Targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States