Product Details
| Product Name:
DMP 696 |
CAS No.:
202578-52-7 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | DMP 696 |
| Description | DMP 696 is a selective antagonist of corticotropin-releasing hormone receptor 1. It is used for the treatment of anxiety and depression. |
| In vivo | DMP696 treatment decreases levels of LA and BLA pCREB to homecage pCREB levels across all time intervals. DMP696 (3 mg/kg, p.o.) attenuates consolidation of remote fear memories in mice, without affecting expression and retention. Rats treated with DMP696 (1, 3, 10, 30 mg/kg) show minimal freezing during a 2-minute preshock interval. WT mice treated with DMP696 for 1 week starting 24 hours after foot shock display reduced synaptosomal GluR1 levels compared to shocked vehicle-treated controls [1]. DMP696 significantly reduces CREB phosphorylation in LA and BLA but not in CeA. In the CeA, both vehicle- and DMP696-treated rats exhibit higher pCREB expression post-conditioning compared to homecage pCREB levels. Rats in the 30 ng DMP696 group exhibit significantly less freezing compared to vehicle-treated animals [2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | DMP-696 | DMP696 | DMP 696 |
| Inhibitors Related | Urotensin I acetate (83930-33-0 Free base) | Crinecerfont | Astressin acetate | Antalarmin | (R)-Crinecerfont | Tildacerfont | CP 316311 | Tetracosactide acetate | NBI-27914 | Corticotropin-releasing factor (human) acetate | CRF (6-33) acetate(120066-38-8 free base) | K 41498 aceate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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