DO34 NEW
| Price | Get Latest Price |
| Package | 1removed |
| Supply Ability: | 10g |
| Update Time: | 2026-05-13 |
Product Details
| Product Name: DO34 | CAS No.: 1848233-58-8 |
| Purity: 99.55% | Supply Ability: 10g |
| Release date: 2026/05/13 |
Product Introduction
Bioactivity
| Name | DO34 |
| Description | DO34 is a selective and potent diacylglycerol lipase (DAGL-α/β) inhibitor that impairs fear extinction in mice, and can be used to study lipopolysaccharide inflammatory pain. |
| In vitro | DO34 is a potent, selective and centrally active DAGL inhibitor, the efficiency of DAGLα in converting SAG to 2-AG was determined by a real-time fluorescence-based natural substrate assay using membrane lysates from HEK293T cells expressing recombinant human DAGLα, DAGLα IC50 = 6 nM.DO34 is also a potent DAGLβ inhibitor, DAGLβ DO34 is also a potent DAGLβ inhibitor, DAGLβ IC50 = 3-8 nM. [1] |
| In vivo | DO34 reduces 2-AG levels in the brain in a dose- and time-dependent manner and prevents fasting-induced regurgitation in mice, which is typical of cannabinoid CB1 receptor-mediated behavior, and DO34 blocks tonic CB1 activation.DO34 blocks basal PF-EPSCs in AM251-increased MAGL-TKO mice. [2] |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 80 mg/mL (150.51 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (18.81 mM), Sonication is recommended. |
| Keywords | DO-34 | DO34 | DAGLβ | DAGLα | DAGL |
| Related Compound Libraries | Bioactive Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $31.00 |
VIP4Y
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TargetMol Chemicals Inc.
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2026-04-20 | |
|
VIP4Y
|
TargetMol Chemicals Inc.
|
2026-05-13 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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