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Postion:Product Catalog >Biochemical Engineering>Amino Acids and Derivatives>DOTA-?NHS-?ester
DOTA-?NHS-?ester
  • DOTA-?NHS-?ester

DOTA-?NHS-?ester NEW

Price $40 Get Latest Price
Package 25mg 50mg
Supply Ability: 10g
Update Time: 2026-06-02

Product Details

Product Name: DOTA-?NHS-?ester CAS No.: 170908-81-3
Purity: 99.88% Supply Ability: 10g
Release date: 2026/06/02

Product Introduction

Bioactivity

NameDOTA-?NHS-?ester
DescriptionDOTA-NHS-ester is a linker for affibody molecules with applications in small animal PET, SPECT, and CT. It can be used to label radiotherapeutic agents or imaging probes for tumor detection.
In vitroMETHODS: The binding kinetics of hIMB1636 to Trop2 antigen were measured by biofilm interferometry (BLI). Western blotting was used to screen Trop2 expression in pancreatic cancer cell lines. Flow cytometry and cell immunofluorescence were used to evaluate the binding ability of hIMB1636 and Trop2 on the cell surface. hIMB1636 was conjugated with p-SCN-Bn-NOTA (NOTA) and DOTA-NHS-ester (DOTA) for 64Cu and 177Lu radiolabeling. RESULTS According to the BLI results, hIMB1636 had a strong binding affinity to Trop2. According to the results of Western blotting, flow cytometry, and cell immunofluorescence, the T3M-4 cell line showed the strongest expression of Trop2 and the specific binding ability of hIMB1636. The radiochemical purity of 64Cu-NOTA-hIMB1636 and 177Lu-DOTA-hIMB1636 exceeded 95%. [2]
StorageStore at low temperature,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.99 mM), Sonication is recommended.
10% DMSO+90% Saline : 1.79 mg/mL (3.57 mM), Solution.
DMSO : 17.86 mg/mL (35.61 mM), Sonication is recommended.
Keywordstumor | tomography | SPECT | SKOV3 | single-photon | radiometal | positron | PET | Inhibitor | inhibit | HSA | emission | DOTA-NHS-ester | DOTA?NHS?ester | DOTA ?NHS ?ester | cancer | Antibody-drug conjugates linkers | ADCLinker | ADC Linkers | ADC Linker
Inhibitors RelatedLenalidomide-Br | Boc-C16-COOH | N-(4-Carboxycyclohexylmethyl)maleimide | Azido-PEG1 | Succinic anhydride | Triethylene glycol | 11-Aminoundecanoic acid | 1,3-Dibromo-5,5-dimethylhydantoin | N-Hydroxysulfosuccinimide sodium | m-PEG12-NHS ester | Tetraethylene glycol | Tranexamic acid

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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