Product Details
| Product Name:
Drimenol |
CAS No.:
468-68-8 |
| Purity:
99.97% |
Supply Ability:
10g |
| Release date:
2026/07/08 |
Product Introduction
Bioactivity
| Name | Drimenol |
| Description | Drimenol is a sesquiterpene alcohol derived from edible aromatic plants and possesses broad-spectrum antifungal activity. It exerts its fungicidal effects by disrupting the cell wall/membrane structure of fungi. Drimenol also exhibits cytotoxicity and anticancer potential, and is capable of inducing apoptosis in tumor cells. |
| In vitro | Method: Human pathogenic fungi (e.g., Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus) were treated with drimenol (4–64 μg/mL), and the minimum inhibitory concentration (MIC) was determined using the broth microdilution method.
Result: Drimenol exhibited broad-spectrum fungicidal activity against various fungi, with MIC values of 8 μg/mL against Cryptococcus neoformans and Aspergillus fumigatus, 30–32 μg/mL against Candida albicans (including fluconazole-resistant strains), and 50 μg/mL against Candida auris [1].
Method: Human melanoma cells A2058 and A375 were treated with drimenol (12–25 μM) for 72 h. Cell viability was assessed by MTT assay, DNA fragmentation was detected by TUNEL assay, and the expression levels of Hsp70, Bcl-2, Bax, and caspase-9 were analyzed by Western blot.
Result: Drimenol dose-dependently inhibited the viability of A2058 and A375 cells, with IC50 values of approximately 33.50 μM and 31.25 μM, respectively. It also induced DNA fragmentation, downregulated Hsp70 and Bcl-2, and upregulated Bax and caspase-9, suggesting that drimenol induces apoptosis through the mitochondrial pathway [1]. |
| In vivo | Method: Ehrlich ascites tumor-bearing mice were treated with Siparuna guianensis essential oil containing drimenol (drimenol content: 13.7 ± 0.2%). Tumor cell count, as well as hepatic malondialdehyde (MDA) and superoxide dismutase (SOD) levels, were measured.
Result: The tumor cell count in the treatment group (59.76 ± 12.33) was significantly reduced compared to the untreated control group (96.88 ± 19.15). Additionally, hepatic MDA levels were decreased, and SOD levels were increased, indicating that the essential oil exerts antitumor and antioxidant effects through drimenol [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | Drimenol | Antifection |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Zinc chloride | Dimethyl phthalate | Alginic acid | Sildenafil citrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
| Product name |
Price |
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Suppliers |
Update time |
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$1.00
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VIP7Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2025-12-12 |
United States