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Postion:Product Catalog >DS-6930
DS-6930
  • DS-6930

DS-6930 NEW

Price $2120 $2780 $3700
Package 25mg 50mg 100mg
Supply Ability: 10g
Update Time: 2026-05-21

Product Details

Product Name: DS-6930 CAS No.: 1242328-82-0
Supply Ability: 10g Release date: 2026/05/21

Product Introduction

Bioactivity

NameDS-6930
DescriptionDS-6930 is an potent and selective PPAR γ Agonists with EC50 of 41 nM. DS-6930 can effectively reduce plasma glucose (PG) level, and has less PPARγ-related adverse effects compared with Rosiglitazone. DS-6930 has research value in diabetes.
In vitroDS-6930 demonstrates high in vitro potency with intermediate PPARγ agonist activity (EC50 = 41 nM, Emax = 68%) and exhibits high selectivity for PPARα and PPARδ (13% activation and no activation at 10 μM, respectively) [1]. DS-6930 (10-100 μM) also shows reduced cell toxicity at 100 μM [1].
In vivoDS-6930 administered orally at dosages ranging from 0.1 to 3 mg/kg for three weeks results in a dose-dependent decrease in plasma glucose (PG) levels in rats, with no significant impact on liver enzyme activities and relative heart weight after a higher dosage range of 100 to 1000 mg/kg for four weeks, indicating safety at studied doses. Additionally, pharmacokinetic analysis reveals DS-6930 achieves a maximum concentration (Cmax) of 0.0792 μg/mL and an area under the curve (AUC) of 0.861 h μg/mL 1.8 hours post-administration at a dose of 0.3 mg/kg by day 22 in rats. In cynomolgus monkeys, oral administration shows a Cmax of up to 2.25 μg/mL, a half-life (T1/2) of 13.5 hours, and an AUC of 23.5 h μg/mL at a 3 mg/kg dose, alongside excellent bioavailability (F=89%), total body clearance (CL=2.06 mL/min/kg), and steady-state distribution volume (Vss=0.36 L/kg) following intravenous administration of 1 mg/kg. A specific study in male ZDF rats demonstrates a 47% reduction in PG levels with a 0.3 mg/kg daily oral dose over three weeks, further underscoring DS-6930's efficacy and pharmacokinetic properties in animal models.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Inhibitors RelatedPHYTOL | Rosiglitazone | Retinoic acid | Daidzein | Fenofibrate | Magnesium acetate tetrahydrate | Maltitol | Naringenin | 2,3-Butanediol | NPC 15199 | Icariin | Cloxiquine

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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