DSR-6434 NEW
| Price | $45 | Get Latest Price |
| Package | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: DSR-6434 | CAS No.: 1059070-10-8 |
| Purity: 99.78% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | DSR-6434 |
| Description | DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse. |
| In vitro | To evaluate the specificity of DSR-6434 for TLR7, a NF-κB-driven reporter assay was conducted in HEK293 cells engineered to express hTLR7, TLR8, or TLR9. This assay determines specificity through NF-κB activation upon successful receptor binding. Results demonstrate that DSR-6434 selectively stimulates reporter gene activity in cells expressing hTLR7, but not in those expressing the structurally similar hTLR8 or hTLR9[1]. |
| In vivo | In B6C3F1 mice, DSR-6434 (0.1-1 mg/kg; i.v.) significantly suppresses lung metastasis[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (12.49 mM), Sonication is recommended. DMSO : 225 mg/mL (561.83 mM), Sonication is recommended. |
| Keywords | TLR7 | DSR-6434 | DSR6434 | DSR 6434 |
| Inhibitors Related | D-Glucuronic acid | Hydroxychloroquine | Benzyl alcohol | (±)-Naringenin | Chloroquine phosphate | Chloranil | CU-115 | Thiamine hydrochloride | 2,4,5-Trimethoxybenzoic acid | Resiquimod | Stevioside | DHBP |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | HIF-1 Signaling Pathway Compound Library | Antioxidant Compound Library | Immuno-Oncology Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name | Price | Suppliers | Update time | |
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VIP4Y
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TargetMol Chemicals Inc.
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2026-05-11 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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