(E)-SIS3 NEW
| Price | $36 | $52 | $113 |
| Package | 1mg | 2mg | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-21 |
Product Details
| Product Name: (E)-SIS3 | CAS No.: 521984-48-5 |
| Purity: 98.83% | Supply Ability: 10g |
| Release date: 2026/04/21 |
Product Introduction
Bioactivity
| Name | (E)-SIS3 |
| Description | (E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) and is selective. (E)-SIS3 inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. |
| Cell Research | Normal human dermal fibroblasts are plated at a density of 105 cells/well in six-well culture plates and grown until subconfluence in MEM containing 10% FCS. Cells are quiesced by 24-h incubation in serum-free MEM, followed by incubation in serum-free medium in the presence or absence of SIS3 before the collection of cells for 72 h. Then, the cells are detached from the wells by trypsin treatment and counted using a Coulter counter.(Only for Reference) |
| In vitro | METHODS: Human dermal fibroblasts were treated with (E)-SIS3 (10 μM) for 24 hours, and the expression levels of target proteins were detected by Western Blot and Immunoprecipitation. RESULTS: (E)-SIS3 attenuated TGF-beta1-induced Smad3 phosphorylation and Smad3 / Smad4 interaction. [1] METHODS: Human dermal fibroblasts were treated with (E)-SIS3 (0.1-50 μM) for 30 minutes, and the expression levels of target proteins were detected by Western Blot. RESULTS: (E)-SIS3 significantly inhibited the expression of FN and α-SMA, but not the expression of Sphk2 induced by TGF-β1. [2] METHODS: Human dermal fibroblasts were treated with (E)-SIS3 (10 μM) for 24 hours, and the expression levels of target proteins were detected by Western Blot. RESULTS: (E)-SIS3 significantly decreased the expression of α-SMA and Palladin in primary human dermal fibroblasts. [3] |
| In vivo | SIS3 inhibits Smad3 activation in streptozotocin(STZ)-induced diabetic nephropathy in Tie2-Cre;Loxp-EGFP mice. It also reduces AGE-induced EndoMT and decreases EndoMT in STZ-induced diabetic nephropathy in Tie2-Cre;Loxp-EGFP mice. SIS3 significantly reduces collagen IV and fibronectin expression in the glomeruli and tubulointerstitium of STZ-injected Tie2-Cre;Loxp-EGFP mice, suggesting that SIS3 retards the early development of STZ-induced diabetic glomerulosclerosis and tubulointerstitial fibrosis. However, SIS3 administration does not reduce proteinuria[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 23 mg/mL (46.94 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.73 mM), Sonication is recommended. DMSO : 100 mg/mL (204.09 mM), Sonication and heating are recommended. |
| Keywords | Transforming growth factor beta | TGF-β/Smad | TGFβ | TGF-beta/Smad | TGFbeta/Smad | TGF-beta | TGFbeta | TGF-b/Smad | TGFb | Smad3 | Smad | SIS-3 | SIS3 | SIS 3 | (E)-SIS-3 | (E)-SIS3 | (E)SIS3 | (E) SIS3 |
| Inhibitors Related | Trimethylamine N-oxide | Melamine | SB-431542 | Hydrochlorothiazide | Hippuric acid | Chromenone 1 | Pirfenidone | A 83-01 | Suberic acid | Cetrimonium bromide | Galunisertib | Alantolactone |
| Related Compound Libraries | Highly Selective Inhibitor Library | Osteogenesis Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Anti-Liver Cancer Compound Library | TGF-beta/Smad Compound Library | Neuronal Differentiation Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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