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Postion:Product Catalog >E1R
E1R
  • E1R

E1R NEW

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Package 2mg 25mg 50mg
Supply Ability: 10g
Update Time: 2025-08-23

Product Details

Product Name: E1R CAS No.: 1301211-78-8
Supply Ability: 10g Release date: 2025/08/23

Product Introduction

Bioactivity

NameE1R
DescriptionE1R is a positive sigma-1 receptor (Sig1R PAM) allosteric modulator. It has a cognition-enhancing activity.
In vitroE1R (10?μM) does not displace the radioligand. However, in Jurkat cells, it instead increases the specific binding of a non-selective radioligand ([3H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38%. The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor.
In vivoE1R (0.1-10?mg/kg; i.p. 60?min before the training session) treatment obviously improves cognitive function in a dose-related manner in mice. E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 60 mg/mL (258.31 mM), Sonication is recommended.
KeywordsE-1R | E1R

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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