EC 144 NEW
| Price | $1980 | $2500 |
| Package | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: EC 144 | CAS No.: 911397-80-3 |
| Supply Ability: 10g | Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | EC 144 |
| Description | EC 144, a second-generation selective inhibitor of Hsp90 (heat shock protein 90), inhibits tumor growth with an IC50= 1.1 nM for Hsp90α and an EC50 = 14 nM for degradation of Her-2 in MCF-7 cells. |
| In vitro | EC 144 is a synthetic Hsp90 inhibitor, blocks LPS-induced TLR4 signaling in RAW 264.7 cells by inhibiting activation of ERK1/2, MEK1/2, JNK, and p38 MAPK but not NF-κB. EC 144 inhibited CD4(+) T cell proliferation in both mouse and human mixed lymphocyte reactions (MLRs), indicating an immunosuppressive effect on adaptive immune activation. [1] |
| In vivo | In mice treated with EC 144, peritoneal CD11b(+) exudate cells showed reduced phosphorylation of tumor progression locus 2, MEK1/2, and ERK1/2 upon LPS challenge. This corresponded with resistance to LPS-induced systemic inflammation and suppressed TNF-α release. In a mouse collagen-induced arthritis model, EC 144 suppressed arthritis development, correlated with a reduction in antigen-specific antibody production and impaired activation of antigen-specific CD4(+) T cells. [1] |
| Storage | Keep away from moisture,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.83 mM), Sonication is recommended. DMSO : 50 mg/mL (120.8 mM), Sonication is recommended. |
| Keywords | EC-144 | EC 144 |
| Inhibitors Related | Ethoxyquin | Adezmapimod | Tamoxifen | Palmitic acid sodium | Mequinol | 7-Aminocephalosporanic acid | Benzbromarone | Elesclomol | Rifabutin | Palmitic acid | Tamoxifen Citrate | Isoxazole |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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