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Postion:Product Catalog >Emixustat
Emixustat
  • Emixustat

Emixustat NEW

Price $98 $226 $766
Package 2mg 5mg 25mg
Supply Ability: 10g
Update Time: 2025-08-22

Product Details

Product Name: Emixustat CAS No.: 1141777-14-1
Supply Ability: 10g Release date: 2025/08/22

Product Introduction

Bioactivity

NameEmixustat
DescriptionEmixustat, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro. a novel visual cycle modulator.
In vitroEmixustat strongly inhibits 11-cis-retinol production with an IC50 value of 232±3 nM.Emixustat potently inhibits isomerase activity in vitro (IC50=4.4 nM). Treatment of emixustat shows a concentration dependent reduction of 11-cis-ROL production .
In vivoPre-treatment with a single dose of emixustat (0.3 mg/kg) provides a 50% protective effect against light-induced photoreceptor cell loss, while higher doses (1-3 mg/kg) are nearly 100% effective. In Abca4-/- mice, chronic (3-month) emixustat treatment markedly reduces lipofuscin autofluorescence and lowers A2E levels by 60% (ED50=0.47 mg/kg). In the retinopathy of prematurity rodent model, emixustat administered during ischemia and reperfusion injury results in a 30% reduction in retinal neovascularization (ED50=0.46 mg/kg). Emixustat reduces the production of visual chromophore (11-cis retinal) in wild-type mice after a single oral dose (ED50=0.18 mg/kg). In albino mice, emixustat effectively prevents photoreceptor cell death caused by intense light exposure.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 43 mg/mL (163.26 mM), Sonication is recommended.
Keywordsvisual cycle isomerase | Emixustat | ACU4429 | ACU 4429

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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