Endomorphin 1 acetate NEW
| Price | $30 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-16 |
Product Details
| Product Name: Endomorphin 1 acetate | CAS No.: 1276123-71-7 |
| Purity: 99.74% | Supply Ability: 10g |
| Release date: 2026/07/16 |
Product Introduction
Bioactivity
| Name | Endomorphin 1 acetate |
| Description | Endomorphin 1 acetate is a selective and highly effective μ-opioid receptor agonist with anti-nociceptive and analgesic effects. Endomorphin 1 acetate shows high affinity for kappa3 and can be used to study neurological diseases. |
| In vitro | Caco-2 cells were treated with various concentrations of Endomorphin 1 acetate. When cells were incubated with Endomorphin 1 acetate alone, no changes in basal IL-8 production were detected. However, treatment of Caco-2 cells with Endomorphin 1 acetate in the presence of IL-1β significantly increased IL-8 compared with cells treated with IL-1β alone. [1] |
| In vivo | Male Sprague Dawley rats (n=48) were randomly divided into four groups (n=12/group): i) Sham group, LAD ligation with no other intervention for 150 min; ii) IR group: LAD was ligated for 30 min (ischemia), and was reperfused for 120 min in vivo; iii) IPO group, after 30 min ischemia, three cycles of LAD clamping for 15 sec and declamping for 15 sec were performed before reperfusion; iv) EM50 group: Endomorphin 1 acetate (50 μg/kg) was administered intravenously following LAD ligation for 25 min, subsequently the LAD was reperfused for 120 min in vivo. In the IR, IPO and Endomorphin 1 acetate groups, LDH and CK-MB activities were significantly higher compared with the sham group. Compared with the IR group, LDH and CK-MB activities were significantly decreased in the IPO and Endomorphin 1 acetate groups. In the IR group, IL-6 and TNF-α levels were significantly increased compared with the sham group. Compared with the IR group, IL-6, and TNF-α levels were significantly decreased in the IPO and Endomorphin 1 acetate groups. [2] |
| Storage | Keep away from direct sunlight,Keep away from moisture,Store under nitrogen,Store at low temperature, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (5.96 mM), Sonication is recommended. DMSO : 100 mg/mL (149.09 mM), Sonication is recommended. |
| Keywords | μ-opioid receptor | OpioidReceptor | Opioid Receptor |
| Inhibitors Related | Docusate sodium | Bevenopran | Mirtazapine | Matrine | (-)-Menthol | Cuminaldehyde | Progesterone | Naltrexone hydrochloride | Cebranopadol | BTRX-335140 | Bisacodyl | Mianserin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Peptide Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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