Etanercept NEW
| Price | $328 | $662 | $893 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Etanercept | CAS No.: 185243-69-0 |
| Purity: 98.00% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Etanercept |
| Description | Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.[1] |
| In vitro | METHODS: CHLA-255 cells were co-cultured with human monocytes and treated with etanercept (10 μg/mL). TNF-α levels in the co-culture supernatant were measured by TNF-α ELISA; supernatant IL-6 levels were measured by ELISA. RESULTS Treatment of NB-monocyte co-cultures with etanercept blocked almost all sTNF-α and IL-6 production. Etanercept effectively disrupted the pro-tumorigenic mTNF-α/TNFR2 signaling axis between NB cells and monocytes, preventing NF-κB activation in both cell types. This reduced monocyte pro-tumorigenic cytokine production, ultimately leading to increased apoptosis and decreased proliferation of NB cells in vitro. [1] |
| In vivo | METHODS: Tumor-bearing mice were injected intraperitoneally with etanercept (5 mg/kg) twice a week. Tumor growth was measured by bioluminescence imaging. RESULTS Etanercept treatment reduced tumor growth by 30% (p<0.05). [1] METHODS: Etanercept (10 mg/kg/3 days, subcutaneous injection) or saline was administered in AIA rats for 3 weeks at the first signs of arthritis. Body weight and arthritis scores were monitored daily. RESULTS Etanercept significantly reduced arthritis scores (P < 0.001). [2] |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : Soluble |
| Keywords | TNF | Etanercept |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate | BES |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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