Ethaverine hydrochloride NEW
| Price | $57 | $103 | $177 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-02 |
Product Details
| Product Name: Ethaverine hydrochloride | CAS No.: 985-13-7 |
| Purity: 99.90% | Supply Ability: 10g |
| Release date: 2026/06/02 |
Product Introduction
Bioactivity
| Name | Ethaverine hydrochloride |
| Description | Ethaverine hydrochloride is a homologue of papaverine and is used as a vasodilator and antispasmodic.[2] |
| In vitro | METHODS: The inhibitory effect of ethaverine on dopamine content in PC12 cells was studied. RESULTS Ethaverine reduced dopamine content in PC12 cells in a concentration-dependent manner. At a concentration of 1.0 μM, dopamine content was inhibited by 33.6% within 24-48 hours. The IC50 value of ethaverine was 1.4 μM. 2.0 μM ethaverine reduced dopamine content after 6 hours of action. Tyrosine hydroxylase (TH) was inhibited after 6 hours of ethaverine treatment in PC12 cells, and the activity remained at a reduced level until 36 hours (the inhibition rate was 12-22% at 2.0 μM). [1] Ethaverine (10 μM) treatment in PC12 cells reduces catecholamine secretion by blocking L-type voltage-sensitive Ca2+ channels. [2] |
| In vivo | METHODS: In a short-term experiment on 11 guinea pigs, the effect of Ethaverine hydrochloride on cochlear microcirculation was observed (2/5 and /10 mg/kg, i.v) for 10 minutes. In these experiments, intracochlear PO2, intracochlear potential (EP), cochlear microphonic (CM) potential, and blood pressure (BP) were recorded. Intracochlear PO2 was measured polarographically in the mid-level using gold electrodes. RESULTS Ethaverine hydrochloride at doses of 5 and 10 mg/kg caused a significant increase in intracochlear PO2 for 35 to 90 minutes, even with a temporary decrease in blood pressure. At the same time, this improvement in cochlear microcirculation was observed to coincide with an increase in CM potential. The decrease in EP may be the result of a decrease in blood pressure and a direct effect of Ethaverine hydrochloride on EP production. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 100 mg/mL (231.5 mM), Sonication is recommended. DMSO : 16 mg/mL (37.04 mM), Sonication is recommended. 10% DMSO+90% Saline : 1.6 mg/mL (3.7 mM), Solution. |
| Keywords | MAO | Ethaverine Hydrochloride |
| Inhibitors Related | Quadrol | 2,4,6-Tri-tert-butylphenol | Chlorocresol | L-Ascorbic acid | 1,4-Naphthoquinone | Paeonol | Methylene Blue trihydrate | L-Ascorbic acid sodium salt | β-Aminopropionitrile | 2-Nitrobenzoic acid | Magnesium Chloride Hexahydrate | Magnesium sulfate |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Mitochondrial Membrane Protein-Targeted Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Neuronal Signaling Compound Library | Approved Drug Library | ReFRAME Related Library | Drug Repurposing Compound Library | Mitochondria-Targeted Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
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TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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