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Postion:Product Catalog >Biochemical Engineering>Inhibitors>protein tyrosine kinase>Etomoxir
Etomoxir
  • Etomoxir

Etomoxir NEW

Price $30 $67 $117
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-06-08

Product Details

Product Name: Etomoxir CAS No.: 124083-20-1
Purity: 99.36% Supply Ability: 10g
Release date: 2026/06/08

Product Introduction

Bioactivity

NameEtomoxir
DescriptionEtomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a) (IC50=5-20 nM). Etomoxir inhibits fatty acid oxidation by inhibiting CPT-1a, inhibits palmitate oxidation, has an inhibitory effect on adenine nucleotide translocase, and can inhibit macrophage polarization by disrupting CoA homeostasis.
In vitroMETHODS: A2780/PTX cells were treated with Etomoxir (1, 10, 100, 1000, 10000, 100000 nM) and paclitaxel (1, 10, 100, 1000, 10000, 100000 nM) for 48 hours, and the growth inhibition of the cells was detected by the CCK-8 method. RESULTS: The IC50 value of Etomoxir decreased from 1589.5 ± 62.5 nM to 817.4 ± 79.7 nM. [1]
In vivoMETHODS: To study the inhibition of cardiac CPT-I activity by Etomoxir, rats were injected with Etomoxir daily for 8 consecutive days at a dose of 20 mg/kg. RESULTS: Rats treated with Etomoxir showed a 44% reduction in cardiac CPT-I activity. METHODS: To study the effects of Etomoxir on blood glucose levels, weight gain, hind limb muscle mass, heart mass and liver mass, Lewis rats were treated with 20 mg/kgEtomoxir for 8 days. RESULTS: Treating Lewis rats with Etomoxir for 8 days did not change the blood glucose level, did not affect general growth characteristics such as weight gain, nor did it affect the muscle mass of the hind limbs. However, both the heart mass and liver mass increased significantly by 11%. [2]
StorageStore at low temperature,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information0.5% CMC-Na : 12.5 mg/mL (38.25 mM), Suspension.
DMSO : 250 mg/mL (764.95 mM), Sonication and heating are recommended.
KeywordsEtomoxir | CPT1 | Antioxidant
Inhibitors RelatedStavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate
Related Compound LibrariesBioactive Compound Library | ReFRAME Related Library | Antioxidant Compound Library | Metabolism Compound Library | Lipid Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Human Metabolite Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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