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Postion:Product Catalog >Biochemical Engineering>Inhibitors>DNA damage>ATM / ATR inhibitor>ETP-46464
ETP-46464
  • ETP-46464

ETP-46464 NEW

Price $34 $55 $89
Package 2mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-05-11

Product Details

Product Name: ETP-46464 CAS No.: 1345675-02-6
Purity: 99.56% Supply Ability: 10g
Release date: 2026/05/11

Product Introduction

Bioactivity

NameETP-46464
DescriptionETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
In vivoETP-46464 (1 μM) exhibits inhibitory effects on the G2/M phase checkpoint induced by ionizing radiation, resulting in cells with micronuclei or completely fragmented nuclei. It significantly enhances the toxicity in p53-deficient cells, particularly under replicative stress conditions like cyclin E overexpression, intensifying the toxicity. At a concentration of 100 nM, ETP-46464 can fully inhibit ATR activity. Furthermore, ETP-46464 inhibits the activity of PI3Kα (IC50: 170 nM), mTOR (IC50: 0.6 nM), and DNA-PKcsmTOR (IC50: 36 nM) proteins. It promotes damage due to replication fork stalling and induces extensive DNA damage in replicating cells.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationEthanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 6 mg/mL (12.75 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
KeywordsPI3Kα | mTOR | Mammalian target of Rapamycin | Inhibitor | inhibit | ETP-46464 | ETP46464 | ETP 46464 | DNA-PK | DNAPK | ATR | ATM/ATR | ATM and RAD3 related | ATM | Ataxia telangiectasia mutated
Inhibitors RelatedMusk ketone | Stearamide | L-Leucine | Myricetin | Creatine monohydrate | Hyaluronic acid | L-Proline | Isoprenaline hydrochloride | Metformin | Methyl eugenol | Quercetin | Dihydromyricetin
Related Compound LibrariesGlycometabolism Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Kinase Inhibitor Library | Anti-Breast Cancer Compound Library | Inhibitor Library | NO PAINS Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Neuronal Differentiation Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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