Summary:

Exemestane is an irreversible steroidal aromatase inhibitor with a structure similar to its substrate natural androstenedione. Estrogen deprivation by inhibiting aromatase is an effective and alternative treatment for hormone-dependent breast cancer in postmenopausal women with advanced breast cancer that has not progressed after tamoxifen therapy in natural or artificial postmenopausal women.

Uses:

It is an irreversible steroidal aromatase inactivator, which can inhibit estrogen synthesis and reduce the level of estrogen in blood circulation. It is suitable for advanced postmenopausal breast cancer patients who progress after tamoxifen treatment

Production method: 

Androstene-4-ene-3, 17-dione and triethyl orthoformate are dissolved in tetrahydrofuran and anhydrous ethanol, react in the presence of p-toluenesulfonic acid, and then add n-methylbenzene Chemicalbook amine and formaldehyde solution to continue the reaction. The Mannich reaction product was dissolved in benzoic acid and anhydrous dichethanes, and exemestane was obtained under the action of DDQ with a total yield of 45%.

Synthesis: 6-methylene-androstene-4-ene-3, 17-diketone (3) was synthesized from androstene-4-ene-3, 17-diketone (3) by condensation with triethyl orthoformate, N-methylaniline and 40% formaldehyde solution, and then 1 was prepared by oxidation with 2, 3-dichloro-5 and chemicalbook6-dicyanoquinone (DDQ). Adding a certain amount of weak acid in oxidative dehydrogenation can shorten the reaction time from 15h to 8h, and the yield can be increased from 47% to 62%. The reaction conditions were mild, the separation was simple and the total yield was 45%

hebei yanxi chemical  co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!

1:Safe shipping (TNT;EMS;FEDEX;DHL;UPS;EUB)

2:Safe payment(Btc;MoneyGram;WU)

3:Safe packing (Paraffin coating; Double aluminum foil bag; Vacuum packaging)

4:Fast delivery (3-10 DAYS fast home delivery service )

5:Best quality (Without any doping, all products are pure)

6:Safety guarantee (we do this business long time ,we know how to disguise let the product through customs)

8:New international transportation system(Pls see the pic,The transportation line reaches every corner of the world)

9:Huge Supply(We have many raw materials and processing centers,Each day can provide dozens of kilogram-hundreds of kilograms of different products.)

10:Low Price(All the products are factory prices it can let you have a bigger profit margin)

1.lowest price 

2.good service

3.best quality 

4.rich experience 

5.support sample

Details

hebei yanxi chemical  co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!

1:Safe shipping (TNT;EMS;FEDEX;DHL;UPS;EUB)

2:Safe payment(Btc;MoneyGram;WU)

3:Safe packing (Paraffin coating; Double aluminum foil bag; Vacuum packaging)

4:Fast delivery (3-10 DAYS fast home delivery service )

5:Best quality (Without any doping, all products are pure)

6:Safety guarantee (we do this business long time ,we know how to disguise let the product through customs)

8:New international transportation system(Pls see the pic,The transportation line reaches every corner of the world)

9:Huge Supply(We have many raw materials and processing centers,Each day can provide dozens of kilogram-hundreds of kilograms of different products.)

10:Low Price(All the products are factory prices it can let you have a bigger profit margin)