Product Details
| Product Name:
FA16 |
Purity:
99.81% |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | FA16 |
| Description | FA16 is a selective, metabolically stable ferroptosis inducer with an IC50 value of 1.26 μM.FA16 is a derivative of 2-(trifluoromethyl)benzimidazole.FA16 inhibits the cystine/glutamate inverse transporter protein (system Xc-)-mediated exchange of intracellular glutamate for extracellular cystine.FA16 significantly inhibited tumor growth in a HepG2 xenograft tumor model. HepG2 xenograft tumor model significantly inhibited tumor growth. |
| In vitro | FA16 (15 or 30 mg/kg; intraperitoneal injection; every other day for 21 days; BALB/c nude mice bearing HepG2 tumors (subcutaneously)) significantly inhibited tumor growth in a 786-O xenograft mouse model, with TGI values of 47.6% and 77.1%, respectively.FA16 was safe (did not induce body weight loss), and it also induced tumor tissue iron death occurred. [1] |
| In vivo | FA16 (15 or 30 mg/kg; intraperitoneal injection; every other day for 21 days; BALB/c nude mice bearing HepG2 tumors (subcutaneously)) significantly inhibited tumor growth in a 786-O xenograft mouse model, with TGI values of 47.6% and 77.1%, respectively.FA16 was safe (did not induce body weight loss), and it also induced tumor tissue iron death occurred. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 4.69 mg/mL (10.01 mM), Sonication is recommended.
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| Keywords | Ferroptosis | FA16 |
| Inhibitors Related | Rosiglitazone | Hemin | L-Glutamic acid | Sorafenib | Curcumin | Gallic Acid Monohydrate | L-Cystine | L-Glutamine | (-)-Epigallocatechin Gallate | Coenzyme Q10 | Baicalein | Sodium Molybdate |
| Related Compound Libraries | Ferroptosis Compound Library | Apoptosis Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States