Factory Provide Pharmaceutical Intermediate Fasudil HCl Powder CAS 105628-07-7 Fasudil Hydrochloride

Introduction

Product Name :  Fasudil Hydrochloride

Other name:1-(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE;Fasudil Monohydrochloride;(5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE, 2HCL;

CAS No.: 105628-07-7

Molecular Formula: C14H18ClN3O2S

Molecular Weight: 327.83

Specification:99%

Appearance: White powder or crystal 

Melting Point :220.5°; mp 219.3° (Shirotani)

Solubili :Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.

Storage :Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Fasudil hydrochloride, a novel calcium antagonistic vasodilator, was marketed for the treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). Fasudil is also a potent inhibitor of myosin light chain kinase and protein kinase C. In contrast to other calcium channel blockers, which regulate the influx of calcium ions through the cell membrane but not involved in the intracellular regulatory mechanism of the calcium, fasudil was suggested to have an intracellular mode of action in relaxing vascular smooth muscle. In patients with neurological deficits due to vasospasm, fasudil decreased the occurrence of angiographic severe and symptomatic vasospasm and cerebral infarction without decreasing systemic blood pressure. Fasudil is reportedly in clinical trials for acute ischemic stroke, sequelae of cerebral vascular diseases and angina pectoris.

Function
Fasudil hydrochloride can promote the recovery of nerve function, relieve clinical symptoms and reduce the rate of disability. Therefore, ultra-early thrombolytic therapy can not be realized at the grass-roots level due to the restriction of economic conditions and awareness of diseases. However, in order to reduce the further progress of diseases, it is very important to reconstruct local blood circulation within the treatment time window. Fasudil hydrochloride has significant neuroprotective and therapeutic effects on ischemic cerebrovascular diseases, which is worthy of clinical use, especially at the grass-roots level, to reduce the disability rate and improve the quality of life.

Application
Fasudil Hydrochloride is a new drug with a wide range of pharmacological effects, developed by Asahi Kasei Corporation (Japan.) It is a cardiovascular and cerebrovascular drug which improves symptoms of ischemic cerebrovascular disease such as cerebral vasospasm following subarachnoid hemorrhage. It has significant neuroprotective and therapeutic effects for ischemic cerebrovascular disease, and is suited for clinical use, particularly at the grassroots level to reduce mortality and improve quality of life.