Febuxostat NEW
| Price | $32 | $52 | $80 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-27 |
Product Details
| Product Name: Febuxostat | CAS No.: 144060-53-7 |
| Purity: 99.46% | Supply Ability: 10g |
| Release date: 2026/07/27 |
Product Introduction
Bioactivity
| Name | Febuxostat |
| Description | Febuxostat (TEI 6720) is a xanthine oxidase inhibitor. |
| In vitro | When compared to L-isomer of sugar alone, Febuxostat (5–6 mg/kg/day) in combination with L-isomer of sugar significantly lowered uric acid, blood pressure, insulin, and triglyceride levels in rats; the combination also reduced renal vasoconstriction, glomerular pressure, and afferent arteriole constriction. Febuxostat prevented hyperuricemia, improved proteinuria, and protected renal function in rats treated with 5/6 nephrectomy (5/6 Nx) + oxonic acid (OA) + Febuxostat (Fx), and it also prevented glomerular hypertension in 5/6 Nx + vehicle (V)/OA + Febuxostat (Fx) treated rats. Post-transverse aortic constriction (TAC), Febuxostat (5 mg/kg/day, administered forcefully for 8 days) attenuated TAC-induced left ventricular (LV) hypertrophy and dysfunction. It further attenuated the increase in nitrotyrosine (indicating reduced myocardial oxidative stress), p-mTOR(Ser2488), and p-Erk(Thr202/Tyr204), without affecting total mTOR or Erk levels. Based on evaluations of nitrotyrosine, urinary 8-isoprostane, and thiobarbituric acid reactive substances, Febuxostat significantly inhibited the activity of oxonic acid and reduced oxidative stress in the kidneys of Sprague-Dawley rats with unilateral right nephrectomy and left kidney ischemia/reperfusion (I/R) injury. Febuxostat also decreased endoplasmic reticulum stress induction in these rats, as reflected by the assessment of ATF4, GRP-78, and CHOP markers. |
| In vivo | Febuxostat inhibits the activity of mixed-type purified bovine milk xanthine oxidase, with Ki and Ki' values of 0.6 nM and 3.1 nM, respectively, and is also effective against both reduced and oxidized forms of xanthine oxidase. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (158.04 mM), Sonication is recommended. Ethanol : 15.8 mg/mL (49.94 mM), Sonication is recommended. 10% DMSO+90% Corn Oil : 2.5 mg/mL (7.9 mM), Sonication is recommended. |
| Keywords | XO | XanthineOxidase | Xanthine Oxidase | TMX-67 | TMX67 | TEI-6720 | TEI6720 | p-mTOR | p-Erk | metabolic syndrome | Inhibitor | inhibit | Hyperuricemia | gout | Febuxostat |
| Inhibitors Related | Ethoxyquin | Kaolin | Allopurinol | Imeglimin hydrochloride | Triphenyl phosphate | Ethyl linoleate | Magnesium acetate tetrahydrate | Inosine | L-Cystine | L-Ascorbic acid sodium salt | Dimethyl phthalate | 6-PPD |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Pediatric Drug Library | EMA Approved Drug Library | Toxic Compound Library | Antioxidant Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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