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Postion:Product Catalog >Biochemical Engineering>Plant extracts>Plant Extracts>Fingolimod
Fingolimod
  • Fingolimod

Fingolimod NEW

Price $50 $126
Package 100mg 500mg
Supply Ability: 10g
Update Time: 2026-06-05

Product Details

Product Name: Fingolimod CAS No.: 162359-55-9
Purity: 99.53% Supply Ability: 10g
Release date: 2026/06/05

Product Introduction

Bioactivity

NameFingolimod
DescriptionFingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
Cell ResearchSciatic nerve crush was performed in wildtype C57BL/6, in immunodeficient Rag1 (-/-) and Foxn1 (-/-) mice.?Analyses were based on walking track analysis and electrophysiology, histology, and cAMP formation.?Quantification of different LPA species was performed by liquid chromatography coupled to tandem mass spectrometry.?Furthermore, functional consequences of autotaxin inhibition by the specific inhibitor PF-8380 and the impact of fingolimod on early cytokine release in the injured sciatic nerve were investigated[1].
In vitroFingolimod has been reported to reduce LPA synthesis via inhibition of the lysophospholipase autotaxin.?Fingolimod treatment correlates with a significant elevation of axonal cAMP, a crucial factor for axonal outgrowth.?Additionally, Fingolimod significantly reduces LPA levels in the injured nerve.?PF-8380 treatment correlates with improved myelin thickness[1]
StorageKeep away from direct sunlight,Store at low temperature,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationMethanol : 30 mg/mL (97.57 mM), Sonication is recommended.
Ethanol : 7.69 mg/mL (25.01 mM), Sonication is recommended.
DMSO : 1 mg/mL (3.25 mM), Sonication is recommended.
KeywordsS1PReceptor | S1P Receptor | S1P | PAK | p21 activated kinases | Lysophospholipid Receptor | LPLReceptor | LPL Receptor | LPL | Inhibitor | inhibit | FTY720 | FTY 720 | Fingolimod
Inhibitors RelatedLX-2931 | Tyloxapol | Sphingosine-1-phosphate | ASP-4058 | CAY10444 | Ki16198 | Siponimod | 5-Aminosalicylic Acid | CYM5181 | Poloxamer 407 | S1PR1 modulator 1 | MP-A08
Related Compound LibrariesFailed Clinical Trials Compound Library | Alkaloid Natural Product Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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