FKBP12 PROTAC RC32 NEW
| Price | $215 |
| Package | 1mg |
| Supply Ability: | 10g |
| Update Time: | 2025-12-22 |
Product Details
| Product Name: FKBP12 PROTAC RC32 | CAS No.: 2375555-66-9 |
| Purity: 99.57% | Supply Ability: 10g |
| Release date: 2025/12/22 |
Product Introduction
Bioactivity
| Name | FKBP12 PROTAC RC32 |
| Description | FKBP12 PROTAC RC32 is a PROTAC-like degrader targeting FKBP12. It can degrade FKBP12 in organs after intraperitoneal administration. |
| In vitro | RC32 induced FKBP12 degradation in Hep3B and HuH7 with DC50 values at 0.9 and 0.4?nM. [2] RC32 demonstrated the ability for FKBP12 degradation resulted in 50% protein degradation (DC50) of ~0.3?nM after only 12?h of treatment in Jurkat cells. [3] |
| In vivo | The FKBP12 protein in most of the organs of treated mice, except for the brain, was undetectable after only 1 day of treatment with RC32 (intraperitoneal (i.p.) injection, 30?mg/kg, twice a day). A significant degradation of FKBP12 also occurred in the eyes. RC32 had no effect on FKBP12 degradation in brain tissues. [3] When Bama pigs (20?kg) were given RC32 (8?mg/kg, twice a day) for 2 days, the FKBP12 protein was efficiently degraded in most of the organs examined. [3] After 3 days of administration (8?mg/kg, i.p., twice a day), FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of monkeys was efficiently degraded by RC32. [3] |
| Storage | store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 5 mg/mL (3.5 mM), Sonication is recommended. |
| Keywords | RC-32 | RC 32 | PROTAC | FKBP-12 PROTAC RC32 | FKBP12 PROTAC RC32 | Cereblon |
| Inhibitors Related | ARV-393 HCl | Gefitinib-based PROTAC 3 | ACBI1 | ARV-471 | CCT367766 | dBET6 | Dbet57 | dBET1 | AU-15330 | β-NF-JQ1 | DT2216 | C004019 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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