Flavoxate hydrochloride NEW
| Price | $58 |
| Package | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2025-05-07 |
Product Details
| Product Name: Flavoxate hydrochloride | CAS No.: 3717-88-2 |
| Purity: 99.78% | Supply Ability: 10g |
| Release date: 2025/05/07 |
Product Introduction
Bioactivity
| Name | Flavoxate hydrochloride |
| Description | Flavoxate hydrochloride (DW61) , a muscarinic AChR antagonist, is used in the therapy of various urinary syndromes and as an antispasmodic. |
| In vitro | Without altering basal bladder pressure in rats, Flavoxate (3 mg/kg) can halt efferent nerve activity and associated bladder contractions for approximately 10 minutes. At the same dosage, administered intravenously, Flavoxate abolishes rhythmic bladder contractions, with maximum intervals of voiding contractions reaching 7.20 minutes. In rats, at a higher concentration (10 mg/kg), Flavoxate suppresses both the initial rapid-rise contraction phase (Phase 1) and the sustained contraction phase (Phase 2) to an equivalent degree. Furthermore, at this concentration, Flavoxate eliminates bladder contractions without altering contraction amplitude. Intracerebroventricular (ICV) injections of Flavoxate ranging from 50 to 200 mg or intrathecal (IT) injections of 100 to 200 mg dose-dependently abolish rhythmic bladder contractions within 5 to 15 minutes post-administration. |
| In vivo | Flavoxate inhibits cAMP formation in a concentration-dependent manner (0.01~10 μM) from membranes extracted from the rat cerebral cortex and striatum, an effect completely negated by pertussis toxin pretreatment. At concentrations greater than 10 μM, Flavoxate suppresses detrusor muscle contraction induced by acetylcholine, with a pD value of 4.55, and also inhibits contractions induced by Ca2+, with a pIC50 value of 4.92. Flavoxate concentration-dependently reduces K+-induced contractions of human bladder. It can displace [3H]nitrendipine at Ca2+ channel binding sites, with an IC50 of 254 μM. Flavoxate also concentration- and voltage-dependently inhibits the peak amplitude of inward Ba2+ currents sensitive to the voltage-dependent nifedipine in human detrusor smooth muscle cells (Ki: 10 μM), and inhibits the same Ba2+ currents at both 30°C (Ki = 5.1 mM) and 37°C (Ki = 4.6 mM). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 1 mg/mL (2.34 mM), Sonication is recommended. |
| Keywords | Phosphodiesterase (PDE) | Phosphodiesterase | overactive bladder | NSC114649 | NSC 114649 | Muscarinic acetylcholine receptor | muscarinic | mAChR | lower urinary tract infections | Inhibitor | inhibit | Flavoxate hydrochloride | Flavoxate Hydrochloride | Flavoxate | DW-61 | DW 61 | Calcium Channel | Ca2+ channels | Ca channels | antispasmodic | anesthetic |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | Clozapine N-Oxide | Pilocarpine nitrate | Urethane | Ribavirin | D-Menthol | Amitriptyline hydrochloride | Choline chloride | Propoxur |
| Related Compound Libraries | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Anti-Parkinson's Disease Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Neuroprotective Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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