Forodesine NEW
| Price | $59 |
| Package | 2mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-13 |
Product Details
| Product Name: Forodesine | CAS No.: 209799-67-7 |
| Purity: 99.16% | Supply Ability: 10g |
| Release date: 2026/07/13 |
Product Introduction
Bioactivity
| Name | Forodesine |
| Description | Forodesine (BCX-1777) is an orally active and potent purine nucleoside phosphorylase (PNP) inhibitor, a new purine nucleoside analog, inhibitor of human lymphocyte proliferation, induces apoptosis in leukemic cells by increasing dGTP levels, and may be useful in the study of cutaneous T-cell lymphomas. |
| In vitro | Formodicin (10-30 μM; 24 and 48 hours; RPMI-8226, MOLT-4 and 5T33MM cells) has no effect on MM cells at 24 hours, but decreases the percentage of viable cells in MOLT-4 cells by 40% [1]. Treatment with forodosine (10-30 μM; 24 and 48 h; RPMI-8226, MOLT-4 and 5T33MM cells) partially inhibited cell proliferation [1]. In the presence of 2'-deoxyguanosine (dGuo, 3-10 μM), fordifloxacin inhibits the proliferation of human lymphocytes activated by a variety of drugs such as interleukin-2 (IL-2), mixed lymphocyte reaction (MLR) and phytohemagglutinin (PHA) (IC50 values less than 0.1-0.38 μM) [2]. |
| In vivo | Forodesine has excellent oral bioavailability (63%) in mice[2]. Forodesine(single dose of 10 mg/kg; in mice ) treatment, elevates dGuo to approximately 5 μM[2]. Forodesine is effective in prolonging the life span 2-fold or more, in the human peripheral blood lymphocyte severe combined immunodeficiency (hu-PBL-SCID) mouse model[2]. |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (300.47 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (12.39 mM), Sonication is recommended. |
| Keywords | Rat PNP | Purine nucleoside phosphorylase | Mouse PNP | Monkey PNP | Human PNP | Forodesine | Dog PNP | BCX1777 | BCX 1777 | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Urea | Tamoxifen | Cysteamine hydrochloride | Metronidazole | Citric Acid Triammonium | Formamide | Dimethyl phthalate | Alginic acid | Sodium Molybdate | Sildenafil citrate |
| Related Compound Libraries | Failed Clinical Trials Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $15.00 |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-13 | ||
| $15.00 |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-09 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY