Fulvene-5 NEW
| Price | $1980 |
| Package | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2025-07-18 |
Product Details
| Product Name: Fulvene-5 | CAS No.: 1075723-01-1 |
| Supply Ability: 10g | Release date: 2025/07/18 |
Product Introduction
Bioactivity
| Name | Fulvene-5 |
| Description | Fulvene-5 is a chemical compound that exhibits antitumor activity. It functions as a potent inhibitor of NADPH oxidase 4 (NOX4) and possesses antioxidant properties. Additionally, Fulvene-5 acts as a reactive oxygen species (ROS) modifying agent and a powerful radioprotector. |
| In vitro | Fulvene-5, administered at concentrations of 0.5-1.0 μM, significantly reduces the levels of Ang2, delta-like ligand 4 (DLL4), placental growth factor (PLGF), and Nrarp in bEnd.3 cells in a dose-dependent fashion. At a higher concentration (10?μM for 1 hour), Fulvene-5 shifts the adaptive responses of HCT116 TP53 wild type (WT) and HCT116 isogenic TP53 null mutant (Mut) cell cultures from promoting survival towards enhancing sensitivity to radiation, and inversely. These alterations coincide with the moving of survivin into the nuclei in TP53 WT cells and out to the cytoplasm in TP53 Mut cells. Additionally, the involvement of NOX4 in survivin-related adaptive responses is explored by diminishing NOX4 expression through the transfection of HCT116 cells with NOX4 siRNA oligomers, achieving approximately a 50% reduction in NOX4 expression. |
| In vivo | Fulvene-5??treatment potently inhibits hemangioma growth in mice. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | NADPH oxidase 4 (NOX4) | Fulvene-5 | Fulvene5 | Fulvene 5 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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