Fusidic Acid

Definition:
Fusidic Acid is a steroidal antibiotic derived from Fusidium coccineum, effective against various bacterial infections. It is often available in topical and oral formulations, including as a sodium salt.

Function:
Fusidic Acid works by inhibiting bacterial protein synthesis, specifically targeting elongation factor G (EF-G) in bacterial cells. This action prevents bacterial growth and replication, making it effective against Gram-positive bacteria, including Staphylococcus aureus.

Applications:

· Pharmaceutical Industry: Used to treat skin and soft tissue infections, especially those caused by Staphylococcus aureus (including MRSA).

· Topical Treatments: Commonly formulated in creams, ointments, and gels for local application in treating conditions like impetigo, infected wounds, and eye infections.

· Systemic Use: Available in oral or intravenous formulations for more severe infections such as osteomyelitis and endocarditis.