Product Details
| Product Name:
Fuzapladib |
CAS No.:
141283-87-6 |
| Purity:
99.87% |
Supply Ability:
10g |
| Release date:
2026/04/22 |
Product Introduction
Bioactivity
| Name | Fuzapladib |
| Description | Fuzapladib (IS-741) (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of adhesion molecules (integrin) expressed on the inflammatory cell surface to prevent inflammatory cells from adhering to vascular endothelial cells and infiltrating tissue and to control exacerbation of pancreatitis. |
| In vitro | Treatment with Fuzapladib(IS-741) 1μM for 3 h significantly inhibited the adhesion of HL-60 cells to HUVEC stimulated by lipopolysaccharide [1]. |
| In vivo | Oral administration of Fuzapladib(IS-741) 50mg/kg significantly decreased the activity of myeloperoxidase (MPO) and the level of IL-8 in the ileum of rats for 7 consecutive days, and reduced the infiltration of inflammatory lesion multinucleate cells and Mac-1 positive cells, and effectively alleviated the ileitis induced by tritrobenzosulfonate (TNBS)[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.8 mg/mL (10.02 mM), Sonication is recommended.
|
| Keywords | phospholipase A2 | IS741 | IS 741 | Fuzapladib |
| Inhibitors Related | Neomycin sulfate | Levamisole hydrochloride | 1-Naphthaleneacetic acid potassium salt | Difluprednate | trans-Benzylideneacetone | Benzylideneacetone | Omeprazole | Indomethacin | Darapladib | 1-Naphthaleneacetic acid | Lansoprazole | Magnesium sulfate |
| Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Inhibitor Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Cytoskeletal Signaling Pathway Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Hpets Biotech Company (Chongqing) Co.,ltd
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2024-02-27 |
United States