FX-11 NEW
| Price | $41 | $98 | $142 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-15 |
Product Details
| Product Name: FX-11 | CAS No.: 213971-34-7 |
| Purity: 98.95% | Supply Ability: 10g |
| Release date: 2026/05/15 |
Product Introduction
Bioactivity
| Name | FX-11 |
| Description | FX-11 (LDHA Inhibitor FX11) is a highly potent, selective, and competitive inhibitor of lactate dehydrogenase A (LDHA), with a Ki value of 8 μM for LDHA. FX-11 acts as an activator of PKM2 (pyruvate kinase M2). FX-11 exerts its antitumor effects by inhibiting glycolysis, depleting ATP, and inducing oxidative stress and apoptosis. FX-11 can be used in tumor metabolism research. |
| In vitro | Methods: Human breast cancer cells (MCF-7) were cultured under normoxic and hypoxic conditions. Cells were treated with the inhibitor FX-11 at half-logarithmic dilution concentrations (200, 100, 50, 25, 12.5, 0 μM) for 24 hours. Cell viability was assessed using the AlamarBlue assay. Results: FX-11 monotherapy: Inhibited cancer cell proliferation under both normoxic and hypoxic conditions. [1] Methods: Human umbilical vein endothelial cells (HUVEC) were treated with FX-11 (20 μM). After 2 hours, cells were stimulated with LPS (200 ng/mL) for 24 hours to induce inflammation. Immunoblotting was used to detect HIF-1α and LDHA expression levels. Results: FX-11 treatment significantly suppressed LPS-induced upregulation of HIF-1α and LDHA protein expression. [2] |
| In vivo | Methods: C57BL/6J mice were administered FX-11 (10 mg/kg) via intraperitoneal injection. Two hours later, LPS (20 mg/kg) was administered intraperitoneally to induce an acute lung injury model of sepsis. Tissue samples were collected and analyzed after 24 hours. Results: FX-11 pretreatment significantly attenuated LPS-induced pathological damage in lung tissue and markedly reduced HIF-1α and LDHA protein levels in lung tissue. [2] |
| Storage | Store at low temperature,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (14.27 mM), Sonication is recommended. DMSO : 260 mg/mL (741.99 mM), Sonication is recommended. |
| Keywords | LDHA, HeLa cell | LDHA | FX-11 | FX11 | FX 11 |
| Inhibitors Related | Ethoxyquin | Kaolin | Stavudine | Aceglutamide | Allopurinol | Urea | Tamoxifen | Metronidazole | Ethyl linoleate | Formamide | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Ferroptosis Compound Library | Glycometabolism Compound Library | NF-κB Signaling Compound Library | Bioactive Compound Library | Hematonosis Compound Library | Inhibitor Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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