Product Details
| Product Name:
GDC-0310 |
CAS No.:
1788063-52-4 |
| Purity:
99.87% |
Supply Ability:
10g |
| Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | GDC-0310 |
| Description | GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research. |
| In vitro | In vivo, the EC50 and Ki values of GDC-0310 for Nav1.7 were 1.1 μM and 1.8 nM, respectively.[1] |
| In vivo | GDC-0310 demonstrates significantly enhanced selectivity for Nav channels and favorable ADME (Absorption, Distribution, Metabolism, and Excretion) characteristics[1]. GDC-0310 exhibits half-lives (t1/2) of 5 hours in rats (at a dose of 5 mg/kg, intravenously), 46 hours in dogs (1 mg/kg, intravenously), and 4.4 hours in cynomolgus monkeys (2 mg/kg, intravenously)[1]. |
| Storage | Store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3 mg/mL (5.52 mM)
|
| Keywords | GDC-0310 | GDC 0310 |
| Inhibitors Related | Phenytoin sodium | Procaine | Ranolazine dihydrochloride | Tetracaine hydrochloride | Lidocaine | Safinamide | Permethrin | Valproic Acid | L-Aspartic aicd sodium | Lidocaine hydrochloride | Mebeverine hydrochloride | Dibucaine |
| Related Compound Libraries | Bioactive Compound Library | ReFRAME Related Library | Sodium Channel Targeted Library | Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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