一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >GDC-0425
GDC-0425
  • GDC-0425

GDC-0425 NEW

Price $149
Package 2mg
Supply Ability: 10g
Update Time: 2026-04-20

Product Details

Product Name: GDC-0425 CAS No.: 1200129-48-1
Supply Ability: 10g Release date: 2026/04/20

Product Introduction

Bioactivity

NameGDC-0425
DescriptionGDC-0425 (RG-7602) is a potent and highly selective inhibitor of Checkpoint kinase 1 (Chk1). This product blocks DNA damage-induced cell cycle arrest by inhibiting Chk1 activity, forcing damaged cells into mitosis and ultimately leading to apoptosis. Research indicates that the activity of GDC-0425 is modulated by the Ras-MEK signaling pathway, and it significantly enhances tumor regression when combined with DNA-damaging agents like Gemcitabine.
In vitroGDC-0425 dose-dependently inhibits proliferation (0.001-10 mM, 72 h) and induces Chk1 hyperphosphorylation (3 μM, 24 h) in Chk1-positive breast cancer cells. Mechanistic studies demonstrate that GDC-0425-mediated cell death is dependent on Ras-MEK signaling, as blocking this pathway via MEK inhibition or RNAi protects cells from viability loss [3].
In vivoIn NCr nude mice bearing osteosarcoma (143B) or TNBC (HCC1806, HCC70) xenografts, oral GDC-0425 (50-75 mg/kg) partially inhibits tumor growth. Combined treatment with GDC-0425 (administered at 24, 48, and 72 h post-chemo) and Gemcitabine (120 mg/kg, i.p.) leads to significant tumor regression across all models [3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationH2O : 20 mg/mL (62.23 mM), when pH is adjusted to 3 with HCl. Sonication is recommmended.
KeywordsGDC-0425 | GDC0425 | GDC 0425

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$32.00
VIP6Y
TargetMol Chemicals Inc.
2026-06-02
VIP2Y
TargetMol Chemicals Inc.
2026-05-11
$1.10
VIP6Y
Shaanxi Dideu Medichem Co. Ltd
2025-06-25

TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
INQUIRY
吴忠市| 景德镇市| 鄂托克旗| 石嘴山市| 霍邱县| 顺昌县| 平昌县| 百色市| 宜良县| 龙州县| 凤阳县| 嘉义市| 肃宁县| 湘潭县| 阿坝| 忻州市| 丹江口市| 阿尔山市| 万山特区| 廉江市| 玛纳斯县| 通江县| 体育| 五寨县| 法库县| 讷河市| 泰兴市| 八宿县| 陕西省| 白银市| 赤壁市| 花莲县| 石城县| 石家庄市| 新闻| 长泰县| 从化市| 永新县| 贵德县| 芷江| 杭锦后旗|