GNF-6231 NEW
| Price | $43 | $67 | $117 |
| Package | 5mg | 10mg | 25mg |
| Supply Ability: | 10g |
| Update Time: | 2026-04-20 |
Product Details
| Product Name: GNF-6231 | CAS No.: 1243245-18-2 |
| Purity: 99.74% | Supply Ability: 10g |
| Release date: 2026/04/20 |
Product Introduction
Bioactivity
| Name | GNF-6231 |
| Description | GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling. |
| In vitro | GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested[1]. |
| In vivo | GNF-6231 has favorable potency and a PK profile across preclinical species upon oral administration.?The reference for orally in MMTV-Wnt1 tumor-bearing mice is dosed at 3 mg/kg.?GNF-6231 showed very robust dose-related antitumor efficacy[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (5.57 mM), Sonication is recommended. DMSO : 36 mg/mL (80.27 mM), Sonication is recommended. |
| Keywords | Porcupine | GNF-6231 | GNF6231 | GNF 6231 |
| Inhibitors Related | Chlorquinaldol | Urea | Wnt pathway activator 1 | Neohesperidin | XAV-939 | Ethyl linoleate | Monensin sodium salt | Nimbolide | Isoquercetin | (±)-Nornicotine | Methyl Vanillate | Bisdemethoxycurcumin |
| Related Compound Libraries | Highly Selective Inhibitor Library | Bioactive Compound Library | Hematonosis Compound Library | Inhibitor Library | Stem Cell Differentiation Compound Library | Orally Active Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Cytoskeletal Signaling Pathway Compound Library | Wnt/Hedgehog/Notch Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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