GNF362 NEW
| Price | $399 |
| Package | 1mg |
| Supply Ability: | 10g |
| Update Time: | 2025-08-22 |
Product Details
| Product Name: GNF362 | CAS No.: 1003019-41-7 |
| Purity: 99.63% | Supply Ability: 10g |
| Release date: 2025/08/22 |
Product Introduction
Bioactivity
| Name | GNF362 |
| Description | GNF362 is an orally available, selective and potent inhibitor of inositol trisphosphate 3'kinase B (ITPKB), inhibits Itpka and Itpkc, overcomes TMZ chemoresistance, and selectively deletes donor allogeneic reactive T-cells.GNF362 reverses the migratory stimulatory effects of ITPKA overexpression. |
| In vitro | GNF362 blocks Ins(1,3,4,5)P4 production, enhances antigen receptor-mediated Ca2+ responses, and leads to apoptosis of activated T cells in an Itpkb-dependent manner, while augmenting SOC responses with an EC50 value of 12 nM[1]. |
| In vivo | In the Lewis rat antigen-induced arthritis (rAIA) model, GNF362 (6 or 20 mg/kg; oral administration; twice daily; 21 days) reduced knee joint swelling in rats by 47% in the 20 mg/kg treatment group and by 34% in the 6 mg/kg treatment group [1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 40 mg/mL (93.8 mM), Sonication is recommended. DMSO : 80 mg/mL (187.60 mM), Sonication is recommended. |
| Keywords | Itpka | GNF362 |
| Inhibitors Related | PTP1B-IN-22 | Disodium monofluorophosphate | β-Glycerophosphate disodium salt pentahydrate | Idoxuridine | Tartaric acid disodium dihydrate | Cyclosporine | Stearic acid | Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride | CaMKP Inhibitor | L-Ascorbic acid 2-phosphate magnesium | Trimyristin | β-Glycerophosphate disodium salt hydrate |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $399.00 |
VIP4Y
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TargetMol Chemicals Inc.
|
2026-05-11 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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