Product Details
| Product Name:
GSK321 |
CAS No.:
1816331-63-1 |
| Purity:
99.73% |
Supply Ability:
10g |
| Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | GSK321 |
| Description | GSK321 is a selective and potent mutant isocitrate dehydrogenase 1 (IDH1) inhibitor that inhibits lipid synthesis and blocks cell proliferation in OPA1-deficient MEFs and prevents cytoplasmic glutamine reductive carboxylation.GSK321 has been used in the study of leukemia. |
| In vitro | METHODS: R132G IDH1 AML cells were treated with GSK321 (0.01-10 μM) and the intracellular 2-HG level was observed.
RESULTS: The intracellular 2-HG level decreased in a concentration-dependent manner, with an inhibition rate of 78% at a GSK321 concentration of 1.7 μM. [1] |
| Storage | Store at low temperature,Keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 200 mg/mL (398.76 mM), Sonication is recommended.
|
| Keywords | IDH1 | GSK321 |
| Inhibitors Related | Disulfiram | Mycophenolate Mofetil | Rotenone | Ribavirin | 18β-Glycyrrhetinic acid | Benzyl alcohol | 2-Methylaminoethanol | Methotrexate disodium | Dimethyl malonate | Isomalt | D-Mannitol | Ethyl potassium malonate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States