Product Details
| Product Name:
Hepsulfam |
CAS No.:
96892-57-8 |
| Supply Ability:
10g |
Release date:
2026/05/11 |
Product Introduction
Bioactivity
| Name | Hepsulfam |
| Description | Hepsulfam is an anticancer agent. It also displays excellent antileukemic activity (a median IC50: 0.91 μg/mL in a panel of different tumors). |
| In vitro | Hepsulfam exhibits greater toxicity towards L1210 leukemia cells compared to busulfan, its structural analogue, by inducing DNA interstrand cross-links in these cells, an effect not seen with busulfan. This compound also shows increased cytotoxicity against human leukemia (111-60 and K562) and colon carcinoma (BE and HT-29) cell lines relative to busulfan, correlating with higher levels of DNA interstrand cross-links. In a clonogenic assay, hepsulfam demonstrated activity in 22% (8 out of 37) of tumors at a concentration of 1.0 μg/mL. Additionally, it significantly affects human bone marrow cells (CFU-GM) from healthy donors, indicating its potency. In vitro evaluations reveal hepsulfam's superior activity, notably against non-small cell lung cancer, even at tenfold reduced concentrations and extended exposure times (12 h), underscoring its potential therapeutic benefit in a broad spectrum of cancers. |
| In vivo | The preclinical activity of hepsulfam suggests its potential in treating solid human malignancies, demonstrating superior in vivo efficacy in large cell lung cancer xenograft and gastric carcinoma models. However, its increased bone marrow toxicity compared to busulfan may be significant for future clinical applications[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | ZINC-01574758 | ZINC 01574758 | Tumors | NCI-329680 | NCI329680 | Hepsulfam |
| Inhibitors Related | Cyclophosphamide hydrate | Streptozotocin | Busulfan | ATMP | N-Nitroso-N-methylurea | Tectoquinone | 2-Iodoacetamide | Cyclophosphamide | Methyl methanesulfonate | Temozolomide | Cisplatin | Carmustine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States