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Postion:Product Catalog >Natural Products>Phenols>Hexahydrocurcumin
Hexahydrocurcumin
  • Hexahydrocurcumin

Hexahydrocurcumin NEW

Price $81 $198 $328
Package 1mg 5mg 10mg
Supply Ability: 10g
Update Time: 2026-04-27

Product Details

Product Name: Hexahydrocurcumin CAS No.: 36062-05-2
Purity: 99.88% Supply Ability: 10g
Release date: 2026/04/27

Product Introduction

Bioactivity

NameHexahydrocurcumin
DescriptionHexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
Cell ResearchCell Line: HT-29 cells. Concentration: 0 μM, 5 μM, 10 μM, 25 μM. Incubation Time: 24 hours or 48 hours [1]
Animal ResearchAnimal Model: Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH). Dosage: 50 mg/kg. Administration: Oral administration; daily; for 16 weeks [3]
In vitroHexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) significantly decreased HT-29 colon cancer cell viability in a time- and concentration-dependent manner, with IC50 values of 77.05 μM at 24 hours and 56.95 μM at 48 hours. When combined with 5-fluorouracil (5-FU; 5 μM), Hexahydrocurcumin markedly reduced COX-2 expression without altering COX-1 levels [1]. Moreover, Hexahydrocurcumin (7-14 μM; 24 hours) attenuated LPS-induced prostaglandin E2 (PGE2) increase in murine macrophages (RAW 264.7) in a concentration-dependent manner [2].
In vivoIn colon cancer rats, Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci. Hexahydrocurcumin also markedly decreases COX-2 protein expression [3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.34 mM), Sonication is recommended.
DMSO : 150 mg/mL (400.61 mM), Sonication is recommended.
KeywordsROS | ReactiveOxygenSpecies | Reactive Oxygen Species | Inhibitor | inhibit | Hexahydrocurcumin | Cyclooxygenase | COX-1 | COX
Inhibitors RelatedEthoxyquin | Kaolin | Allopurinol | Cysteamine hydrochloride | Imeglimin hydrochloride | Acetaminophen | Ethyl linoleate | Magnesium acetate tetrahydrate | L-Cystine | L-Ascorbic acid sodium salt | Trometamol | Dimethyl phthalate
Related Compound LibrariesPolyphenolic Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Food as Medicine Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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