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Postion:Product Catalog >HFI-419
HFI-419
  • HFI-419

HFI-419 NEW

Price $1520 $1980 $2500
Package 25mg 50mg 100mg
Supply Ability: 10g
Update Time: 2026-05-21

Product Details

Product Name: HFI-419 CAS No.: 1110650-72-0
Supply Ability: 10g Release date: 2026/05/21

Product Introduction

Bioactivity

NameHFI-419
DescriptionHFI-419 is a potent inhibitor of insulin-regulated aminopeptidase (IRAP) with a K i value of 0.48 μM. It is utilized in research pertaining to cognitive and memory impairments, including Alzheimer's disease, brain trauma, and stroke [1].
In vitroHFI-419 effectively inhibits the Insulin-Regulated Aminopeptidase (IRAP) with a K_i value of 0.48 μM [1]. At a concentration of 1 μM, HFI-419 demonstrates a rapid decrease in presence, attributed to nonenzymatic processes, including amide hydrolysis [1].
In vivoHFI-419, administered intravenously (i.v) and intraperitoneally (i.p) at doses of 2 mg/kg and 10 mg/kg, demonstrates significant brain exposure and potent inhibition of IRAP [1]. Utilized in a Sprague-Dawley rat model [1], the compound was noted for its brief apparent elimination half-life, high plasma clearance, and extensive volume of distribution, while effectively extending the apparent half-life to 4.6 hours.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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