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Postion:Product Catalog >Natural Products>Flavonoids>Hispidulin
Hispidulin
  • Hispidulin

Hispidulin NEW

Price $77
Package 10mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: Hispidulin CAS No.: 1447-88-7
Purity: 99.87% Supply Ability: 10g
Release date: 2026/04/22

Product Introduction

Bioactivity

NameHispidulin
DescriptionHispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).
Cell ResearchHepG2 cells are treated with different concentrations of hispidulin (50, 100, 200 μM) for 24, 48 and 72 h. Following treatment, cells are further incubated with MTT reagents at 37°C for 4 h before DMSO is added, to dissolve formazan crystals, and absorbance is measured at 570 nm in a microplate reader [2].
Animal ResearchThe tumor is established in mice. Mice are treated with DMSO or Hispidulin at a dosage of 10, 20 or 40 mg/kg/day for 35 days. The body weight of tumor-bearing mice is recorded every week and tumor volume is calculated [2].
In vitroHispidulin induces cell death in HepG2 cells in a dose- and time-dependent manner. It promotes apoptosis via mitochondrial dysfunction, characterized by a decreased Bcl-2/Bax ratio, disrupted mitochondrial membrane potential, increased cytochrome C release, and activated caspase-3 [2].
In vivoHispidulin treatment effectively mitigates ovariectomy-induced body and bone loss while reducing trabecular spacing in mice [3]. When administered intraperitoneally (10 or 50mg/kg) 30 minutes prior to kainic acid injection (15mg/kg), hispidulin increases seizure latency and lowers seizure scores in rats. Furthermore, it significantly reduces hippocampal neuronal cell death caused by kainic acid, an effect paralleled by diminished microglial activation and decreased production of proinflammatory cytokines, including interleukin-1β, interleukin-6, and tumor necrosis factor-α in the hippocampus [4].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationH2O : Insoluble
DMSO : 60 mg/mL (199.83 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (6.66 mM), Sonication is recommended.
KeywordsPim1 | Pim kinases | Pim | Inhibitor | inhibit | Hispidulin
Inhibitors RelatedTCS-PIM-1-4a | SGI-1776 | CK2/ERK8-IN-1 | M-110 | NSC756093 | Protein Kinase Inhibitor 12 | Pim-1 kinase inhibitor 4 | AZD1208 | Pim-1/2 kinase inhibitor 1 | Pim-1 kinase inhibitor 8 | TP-3654 | K00135
Related Compound LibrariesAnti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Kinase Inhibitor Library | Natural Product Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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TargetMol Chemicals Inc.

4YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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