Histamine NEW
| Price | $34 | $48 |
| Package | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-06-01 |
Product Details
| Product Name: Histamine | CAS No.: 51-45-6 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2026/06/01 |
Product Introduction
Bioactivity
| Name | Histamine |
| Description | Histamine (Ergamine) is an amine derived from histamine through enzymatic decarboxylation; it acts as a histamine receptor agonist and vasodilator. Histamine is an organic nitrogen compound that participates in local immune responses and regulates intestinal physiological functions. Histamine is a potent stimulant of gastric secretion, a bronchoconstrictor, a vasodilator, and a centrally acting neurotransmitter. Histamine influences the p38 MAPK/Akt signaling pathway and exhibits antitumor, antioxidant, and anti-inflammatory activities. Histamine can be used in research on acute myeloid leukemia, malignant melanoma, and renal cell carcinoma. |
| In vitro | Methods: Sympathetic preganglionic neurons (SPNs) in thoracolumbar spinal cord slices from newborn (6–14 days old) Wistar Kyoto rats were perfused with histamine (100 μM) for 15–120 seconds in the bath. Whole-cell current clamp recordings measured membrane potential and input resistance changes. Results: Histamine treatment induced depolarization in 69.6% (16/23) of cells (mean 4.5 mV), accompanied by an increase in input resistance (16.9%).[1] |
| In vivo | Methods: Adult C57BL/6J mice were first administered LPS (1 or 2 mg/kg) via intraperitoneal injection. Two days later, they received an intracerebroventricular injection of histamine (100 μM) or a control solution into the hippocampus. After an additional two days, the mice were euthanized. Western blot analysis was performed to detect hippocampal tissue levels of GFAP (astrocytes) and Iba-1 (microglia) proteins. Results: LPS (2 mg/kg) alone significantly increased GFAP and Iba-1 expression. Histamine treatment significantly reversed LPS-induced elevation of GFAP and Iba-1. [2] |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 260 mg/mL (2339.18 mM), Sonication is recommended. |
| Keywords | Inhibitor | inhibit | HT | HistamineReceptor | Histamine Receptor | Histamine | EndogenousMetabolite | Endogenous Metabolite | 5HTReceptor | 5HT Receptor |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium | DL-Lysine |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Traditional Chinese Medicine Monomer Library | Drug Repurposing Compound Library | Natural Product Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Human Endogenous Metabolite Library | Food as Medicine Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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