Honokiol NEW
| Price | $50 | $63 |
| Package | 50mg | 100mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-25 |
Product Details
| Product Name: Honokiol | CAS No.: 35354-74-6 |
| Purity: 99.67% | Supply Ability: 10g |
| Release date: 2026/05/25 |
Product Introduction
Bioactivity
| Name | Honokiol |
| Description | Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2. |
| Cell Research | Honokiol is dissolved in DMSO. In cytotoxicity assays, 10,000 cells/well are added to 96 wells plates and incubated overnight, thereafter cells are treated with different concentrations of Honokiol dissolved in dimethylsulphoxide (DMSO). Since Honokiol is not soluble in aqueous solvents, for in vitro studies Honokiol is dissolved in DMSO. To study the possible effect of DMSO on cells, solvent (DMSO) control is used at highest concentration of <0.1%. After 72 h treatment, cells are fixed and cell viability is measured by crystal violet staining (0.05%). |
| In vitro | Honokiol exhibits direct antiangiogenic activity by blocking the phosphorylation and racemization triggered by VEGF-VEGFR2 interaction. It promotes apoptosis in CLL cells through the activation of caspase 8, which then activates caspase 9 and 3. Honokiol demonstrates pro-apoptotic effects in cell lines of melanoma, sarcoma, myeloma, leukemia, bladder cancer, lung cancer, prostate cancer, oral squamous cell carcinoma, and colon cancer. It effectively induces apoptosis in SVR sarcoma cells and inhibits the survival of CLL cells mediated by interleukin-4, enhancing the cytotoxicity of bendamustine, fludarabine, and cladribine. Honokiol kills myeloma cells in relapsed patients at doses that do not harm PBMCs. Treatment with Honokiol reduces the phosphorylation of MAP, akt, and c-src in SVR cells. Moreover, Honokiol treatment induces the cleavage of caspase 3, 7, 8, 9, and PARP. It also induces apoptosis in colon cancer cells RKO, enhances apoptosis, and suppresses osteoclastogenesis and invasiveness by regulating the NF-κB activation pathway. |
| In vivo | Honokiol inhibits the growth of RKO cell tumors in transplanted mice and effectively counters SVR sarcoma in nude mice. Furthermore, when treating transplanted tumors in mice, Honokiol suppresses the growth of MDA-MD-231 breast cancer cells. |
| Storage | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 26.6 mg/mL (99.88 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (18.77 mM), Sonication is recommended. DMSO : 255 mg/mL (957.46 mM), Sonication is recommended. |
| Keywords | Protein kinase B | PKB | P-Akt | NSC-293100 | NSC293100 | MEK | Inhibitor | inhibit | Honokiol | Hepatitis C virus | HCVProtease | HCV Protease | HCV | Extracellular signal regulated kinases | ERK | Autophagy | Akt |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Ethyl linoleate | Paeonol | Naringin | Gluconate Calcium | Alginic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Polyphenolic Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Kinase Inhibitor Library | Selected Plant-Sourced Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Miao medicine Compound Library | Cosmetic Ingredient Compound Library | Anti-Aging Compound Library | Food as Medicine Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
|
VIP5Y
|
Changsha Staherb Natural Ingredients Co., Ltd.
|
2026-07-07 | ||
|
VIP2Y
|
Shaanxi Xianhe Biotech Co., Ltd
|
2026-06-23 | ||
|
VIP1Y
|
Jinan Ruitong Biotech Co., Ltd.
|
2026-06-08 | ||
| $1.90 |
VIP6Y
|
Hebei Chuanghai Biotechnology Co,.LTD
|
2026-05-28 | |
|
VIP3Y
|
BINBO BIOLOGICAL CO.,LTD
|
2026-05-22 | ||
| $298.00 |
VIP6Y
|
Baoji Guokang Healthchem Co., Ltd.
|
2026-05-15 | |
| $1.00 |
Hebei Chuanghai Biotechnology Co., Ltd
|
2026-03-20 | ||
| $55.00 |
Hebei Zhuanglai Chemical Trading Co Ltd
|
2025-05-23 | ||
| $320.00 |
VIP5Y
|
ZhenYiBio Technology Inc
|
2025-04-16 | |
|
VIP3Y
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
2025-04-02 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY