HP-β-CD NEW
| Price | $33 |
| Package | 500mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-19 |
Product Details
| Product Name: HP-β-CD | CAS No.: 128446-35-5 |
| Purity: 98.00% | Supply Ability: 10g |
| Release date: 2026/05/19 |
Product Introduction
Bioactivity
| Name | HP-β-CD |
| Description | HP-β-CD (Hydroxypropyl betadex) is a water-soluble cyclodextrin derivative obtained by hydroxypropylation of β-cyclodextrin. HP-β-CD serves as a drug delivery carrier that enhances stability and bioavailability. |
| In vitro | Methods: Cheliensisin A native compound and its HP-β-CD inclusion complex (compound:HP-β-CD molar ratio 1:2) were added to SW1116, SMMC-7721, and HEK293T cells. Drug concentration gradient: 0–100 μM. Treatment duration: 24 hours. Cell viability was assessed using the MTT assay. Results: The inclusion complex significantly enhanced cytotoxicity against tumor cells. For SW1116 cells, the IC?? of the cheliensisin A inclusion complex decreased from 93.2 to 51.4 μM. The inclusion complex also exhibited increased toxicity toward HEK293T cells. [1] Methods: Human aortic smooth muscle cells (HASMCs) were treated with HP-β-CD (6, 8, 10 mg/mL) for 24 h, followed by Western blot analysis of apoptosis markers. Results: HP-β-CD dose-dependently inhibited VSMC apoptosis. [2] |
| In vivo | Methods: Male C57BL/6J mice were used in a PCSK9/angiotensin II (AngII)-induced AAA model. HP-β-CD (200 μl/mouse) was administered intraperitoneally twice weekly starting at the initiation of AngII infusion, continuing for 4 weeks. Results: HP-β-CD significantly reduced the maximum diameter of the abdominal aorta and the incidence of AAA, while also mitigating elastin degradation and VSMC apoptosis. [2] |
| Storage | Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 45.00 mg/mL (29.19 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2 mg/mL (1.3 mM), Sonication is recommended. H2O : 50.00 mg/mL (32.43 mM), Sonication is recommended. |
| Keywords | Inhibitor | inhibit | Hydroxypropyl-beta-cyclodextrin | Hydroxypropyl-b-cyclodextrin | HP-beta-CD | HP-b-CD | (2Hydroxypropyl)βcyclodextrin | (2 Hydroxypropyl) β cyclodextrin |
| Related Compound Libraries | NO PAINS Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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