Hypocrellin A NEW
| Price | $47 | $122 | $197 |
| Package | 1mg | 5mg | 10mg |
| Supply Ability: | 10g |
| Update Time: | 2026-05-11 |
Product Details
| Product Name: Hypocrellin A | CAS No.: 77029-83-5 |
| Purity: 99.36% | Supply Ability: 10g |
| Release date: 2026/05/11 |
Product Introduction
Bioactivity
| Name | Hypocrellin A |
| Description | Hypocrellin A is a natural PKC inhibitor with light-induced antitumor, antifungal and antiviral activities and also exerts immunomodulatory effects on MHC-restricted antigen presentation. |
| Cell Research | Cells were seeded in 96-well plates at a density of 1*10^4 cells in a final volume of 100 μl and maintained in DMEM medium at 37℃ ?.?After cells were treated with different concentrations of HA (5, 10, 20, 40, 80 μM), 20 μl 5 mg/ml MTT solution were added to each well and incubated for 4 h in the incubator.?Then 150 μl DMSO were added to each well to dissolve the pellet, keep it in the dark for 15 min, and dissolve the crystal completely.?Automatic microplate reader measured at 490 nm optical density (OD value).?The experiment was repeated three times.?For combination test, cells were treated with 20 μM Hypocrellin A?and different?concentrations of OA(25,50,100, 200 μM) . |
| In vitro | Method: Three NSCLC cell lines H460, PC-9 and H19755 were treated with 0.01μM, 0.1μM, 0.5μM, 1μM, 5μM, 10μM, 50μM and 100μM HA for 48 hours, and IC50 was determined. RESULTS The IC50 of Hypocrellin A against H1975, H460 and PC-9 were 0.2223μM, 0.2706μM and 0.6223μM respectively. [1] METHODS: A549 cells were collected 12 or 24 h after 24 h treatment with 0.08 μmol/L Hypocrellin A-PDT and apoptosis was measured, aliquots of cell lysates were separated by SDS-PAGE, and lysates were analyzed by Western blotting PARP-1 levels. RESULTS Hypocrellin A-mediated PDT significantly increased the apoptotic population of A549 cells, collectively showing an increase in the proportion of cells in the S phase and G2-M phase, and a decrease in the proportion of cells in the G0-G1 phase, and PARP cleavage in Hypocrellin A begins to occur 3 hours after PDT. [2] METHODS: The isolated tissues of the liver and soleus skeletal muscle parts of the insulin target tissues of obese Zucker rats were treated with Hypocrellin A at concentrations of 0.01, 0.1, 1.0 and 10μg/ml respectively, and the activity of PKC enzyme was measured. RESULTS The IC50 value of Hypocrellin A on liver PKC activity was 0.07μg/ml, and the IC50 value on soleus muscle PKC activity was 0.26μg/ml. [3] |
| In vivo | METHODS: H460 cells were transplanted into athymic female BALB/c nude mice. The mice in the experimental group were intraperitoneally injected with 2.5 mg/kg and 5 mg/kg Hypocrellin A every other day, and the tumor volume of the mice was observed. RESULTS Hypocrellin A reduced NSCLC tumor weight and volume in a concentration-dependent manner. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 19.23 mg/mL (35.19 mM), Sonication and heating are recommended. |
| Keywords | Protein kinase C | PKC | Parasite | Inhibitor | inhibit | Hypocrellin A | Bacterial |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | Emtricitabine | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Fenpyroximate | Formamide | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Fungal Compound Library | Natural Product Library | Microbial Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Anti-infective Natural Product Library | Anti-Cancer Active Compound Library | TGF-beta/Smad Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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