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Postion:Product Catalog >Hypothemycin
Hypothemycin
  • Hypothemycin

Hypothemycin NEW

Price $498 $2360
Package 1mg 5mg
Supply Ability: 10g
Update Time: 2026-04-22

Product Details

Product Name: Hypothemycin CAS No.: 76958-67-3
Supply Ability: 10g Release date: 2026/04/22

Product Introduction

Bioactivity

NameHypothemycin
DescriptionHypothemycin is a fungal polyketide and is a multikinase inhibitor (Kis: 10/70 nM, 17/38 nM, 90 nM, 900 nM/1.5 μM, and 8.4/2.4 μM for VEGFR2/VEGFR1, MEK1/MEK2, FLT-3, PDGFRβ/PDGFRα, and ERK1/ERK2, respectively).
In vitroHypothemycin demonstrates inhibitory activity against a range of mutated cells: it targets EOL1 eosinophilic cells with FIP1L1-PDGFRα mutations, MV-4-11 acute myeloid leukemia cells with FLT3-ITD mutations, and COLO829 melanoma cells with BRAF V600E mutations, displaying IC50 values of 0.4 nM, 6 nM, and 50 nM, respectively. Additionally, it inhibits HUVEC cells with VEGFR mutations, P815 mastocytoma cells with c-KIT D814Y mutations, A459 non-small cell lung cancer (NSCLC) cells with KRAS mutations, and SKOV-3 ovarian cells with HER2 mutations, with IC50 values of 70 nM, 370 nM, 6.0 μM, and 7.0 μM, respectively.
In vivoHypothemycin (10 mg/kg) eradicates T. brucei in infected mice, fully curing one-third of them, though higher doses (>10 mg/kg) result in side effects.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
KeywordsVEGFR2 | VEGFR1 | PDGFRβ | PDGFRα | MEK2 | MEK1 | Hypothemycin | FLT-3 | ERK2 | ERK1
Inhibitors RelatedRibociclib | TBHQ | Urea | Gum arabic | L-Cysteine | Sorafenib | Lactose | Tauroursodeoxycholate | Chloramphenicol | Gluconate Calcium | β-Glycerophosphate disodium salt hydrate | Pazopanib

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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6YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, MA
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