一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

Welcome to chemicalbook!
+1 (818) 612-2111
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >I-287
I-287
  • I-287

I-287 NEW

Price $3180
Package 50mg
Supply Ability: 10g
Update Time: 2026-05-19

Product Details

Product Name: I-287 CAS No.: 2014368-93-3
Supply Ability: 10g Release date: 2026/05/19

Product Introduction

Bioactivity

NameI-287
DescriptionI-287 is a selective, orally active PAR2 inhibitor that functions as a negative allosteric modulator of Gαq and Gα12/13 activity and their downstream effectors. It has been shown to attenuate Complete Freund's adjuvant-induced inflammation in mice, suggesting its utility in inflammation/immunology research [1].
In vitroI-287 (0-60 μM; 15-30 minutes) inhibits PAR2-mediated activation of Gαq and Gα12/13 proteins in HEK-293 cells without affecting Gi/o proteins and does not impact β-arrestin 2 recruitment or receptor internalization [1]. Additionally, I-287 (0-60 μM; 15-30 minutes) suppresses PAR2-mediated ERK1/2 activation [1]. At 10 μM for 30 minutes, I-287 also inhibits PAR2-induced IL-8 secretion in HCT-116 and A549 cells [1].
In vivoI-287 (orally administered at a dosage of 50 mg/kg) reduced the inflammatory response induced by Complete Freund's adjuvant in C57BL/6J mice [1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Inhibitors RelatedTBHQ | Urea | Gum arabic | L-Cysteine | β-Glycerophosphate disodium salt pentahydrate | 4-Methylbenzylidene camphor | Lactose | Astragaloside IV | Tauroursodeoxycholate | Propoxur | Gluconate Calcium | β-Glycerophosphate disodium salt hydrate

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$60.00
VIP6Y
TargetMol Chemicals Inc.
2026-05-26
VIP2Y
Shaanxi Xianhe Biotech Co., Ltd
2026-06-02
VIP1Y
Hefei Lbao Physical & Chemical Science Co.,Ltd
2026-05-18

TargetMol Chemicals Inc.

2YR United StatesUnited States
  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY
平和县| 杭锦后旗| 吕梁市| 阿拉善左旗| 迁西县| 治县。| 阿拉善左旗| 平乐县| 汪清县| 望奎县| 乐平市| 云南省| 克什克腾旗| 淅川县| 红河县| 同仁县| 平山县| 泾源县| 元朗区| 井研县| 莆田市| 江源县| 兖州市| 东莞市| 梁平县| 靖宇县| 依兰县| 昌宁县| 新巴尔虎左旗| 沁阳市| 临西县| 高州市| 应用必备| 宜君县| 沂南县| 调兵山市| 沙田区| 江西省| 沭阳县| 靖江市| 丘北县|