IDO1/TDO-IN-4 NEW
| Price | $106 |
| Package | 5mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-14 |
Product Details
| Product Name: IDO1/TDO-IN-4 | CAS No.: 461424-21-5 |
| Purity: 98.12% | Supply Ability: 10g |
| Release date: 2026/07/14 |
Product Introduction
Bioactivity
| Name | IDO1/TDO-IN-4 |
| Description | IDO1/TDO-IN-4 is a novel dual inhibitor of IDO1/TDO with antidepressant activity, forming hydrogen bonds with IDO1 and π-π stacking interactions with TDO. IDO1/TDO-IN-4 rescues lipopolysaccharide-induced depressive-like behaviors in mice, used for cancer and Alzheimer's disease research. |
| In vitro | IDO1/TDO-IN-4 has dual inhibition on IDO1 and TDO with IC50 values of 3.53 μM and 1.15 μM, respectively. IDO1/TDO-IN-4 (0-2 μM, 1 h) can inhibit the activity of BV2 microglia induced by LPS. [1] |
| In vivo | IDO1/TDO-IN-4 (20 mg/kg) also salvaged lipopolysaccharids-induced depression-like behavior IN mice. [1] |
| Storage | Store at low temperature,Keep away from moisture Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 150 mg/mL (640.31 mM), Sonication is recommended. 10% DMSO+90% Saline : 10 mg/mL (42.69 mM), Solution. |
| Inhibitors Related | Palmatine chloride | GNF-PF-3777 | Necrostatin-1 | IDO-IN-7 | TDO-IN-1 | IDO1-IN-28 | Indoximod | Palmatine | Epacadostat | β-Lapachone | IDO-IN-12 | 3-TYP |
| Related Compound Libraries | Bioactive Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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