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Postion:Product Catalog >Biochemical Engineering>Biochemical Reagents>Agonist Inhibitors>Indisulam
Indisulam
  • Indisulam

Indisulam NEW

Price $30 $38 $61
Package 1mg 2mg 5mg
Supply Ability: 10g
Update Time: 2026-06-01

Product Details

Product Name: Indisulam CAS No.: 165668-41-7
Purity: 99.62% Supply Ability: 10g
Release date: 2026/06/01

Product Introduction

Bioactivity

NameIndisulam
DescriptionIndisulam (E 7070) is a carbonic anhydrase inhibitor and antitumor CDK inhibitor that targets the G1 phase of the cell cycle by depleting cyclin E, inducing p53 and p21, and inhibiting CDK2, thereby causing a blockade in the G1/S transition.
In vitroIn vitro, indisulam has antiproliferative effects on a wide range of human tumor lines with HCT116 colorectal being the most sensitive and NCI-H596 non-small cell lung cancer (NSCLC) the most resistant (IC50s = 0.11 and 94 μg/ml, respectively). It increases the number of P388 murine leukemia cells in the G1 phase of the cell cycle in a dose-dependent manner and exerts time-dependent cytotoxicity against HCT116 cells.
In vivoIn vivo, indisulam suppresses tumor growth and decreases tumor volume in murine HCT116, SW620, and HCT15 colorectal and LX-1 and PC9 lung cancer xenograft models. Indisulam induces proteasomal degradation of RNA binding motif protein 39 (RBM39) through association with the CUL4-DCAF15 E3 ubiquitin ligase in vitro.It is also an inhibitor of carbonic anhydrase in H. pylori (Ki = 310-562 nM). Formulations containing indisulam are under Clinicalal investigation for the treatment of solid tumors.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility InformationDMSO : 145 mg/mL (375.79 mM), Sonication is recommended.
10% DMSO+90% (20% SBE-β-CD in Saline) : 10 mg/mL (25.92 mM), Suspension.
10% DMSO+90% Saline : < 10 mg/mL (25.92 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (25.92 mM), Suspension.
KeywordsInhibitor | inhibit | Indisulam | E-7070 | E7070 | CDK | CarbonicAnhydrase | Carbonic Anhydrase | Carbonate dehydratase
Inhibitors RelatedRibociclib | Benzenesulfonamide | Urea | Sodium Dihydrogen Phosphate | 2-Chloropyrazine | Kojic acid | Cyclamic acid sodium | Hydrochlorothiazide | Abemaciclib | Lenalidomide | Palbociclib | Acesulfame
Related Compound LibrariesBioactive Compound Library | ReFRAME Related Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | NO PAINS Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-COVID-19 Compound Library | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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