Product Details
| Product Name:
INDY |
CAS No.:
1169755-45-6 |
| Purity:
99.26% |
Supply Ability:
10g |
| Release date:
2026/07/14 |
Product Introduction
Bioactivity
| Name | INDY |
| Description | INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively. |
| In vitro | INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM[1]. |
| In vivo | In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+90% Saline : 3.57 mg/mL (15.17 mM), Suspension.
DMSO : 35.71 mg/mL (151.76 mM), Sonication is recommended.
|
| Keywords | INDY | Dyrk1B | Dyrk1A |
| Inhibitors Related | ML 315 | EHT 1610 | ARN25068 | MBM-55S | CK2/ERK8-IN-1 | YK-2-69 | AnnH31 | GNF4877 | Harmine hydrochloride | 2-Amino-4-hydroxypyrrolo[2,3- d]pyrimidi | RD0392 | LDN-192960 |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Multi-Target Compound Library | Post-Translational Modification Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Cell Cycle Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
Recommended supplier
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Price |
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Suppliers |
Update time |
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Anhui Ruihan Technology Co., Ltd
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2023-08-21 |
United States