INT-767 NEW
| Price | $399 |
| Package | 1mg |
| Supply Ability: | 10g |
| Update Time: | 2026-07-27 |
Product Details
| Product Name: INT-767 | CAS No.: 1000403-03-1 |
| Purity: 98.00% | Supply Ability: 10g |
| Release date: 2026/07/27 |
Product Introduction
Bioactivity
| Name | INT-767 |
| Description | INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis. |
| In vitro | INT-767 does not inhibit hERG, indicating that this compound should not induce cardiac toxicity because of inhibition of the potassium channel[2]. |
| In vivo | Mice were treated daily with INT-767 (10 and 20 mg/kg) or vehicle alone (40% 2-hydroxypropyl-β-cyclodextrin) via intraperitoneal injection for 2 weeks. The results showed that INT-767 reduced the levels of plasma total cholesterol, high-density lipoprotein cholesterol, and triglycerides in both db/m and db/db mice [2]. |
| Storage | Keep away from moisture,Store at low temperature, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 80 mg/mL (161.73 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (6.67 mM), Sonication is recommended. H2O : 80 mg/mL (161.73 mM), Sonication is recommended. |
| Keywords | TGR5 | INT-767 | INT767 | INT 767 | FXR |
| Inhibitors Related | Stavudine | Aceglutamide | Adenosine | Hemin | Tamoxifen | Sodium 4-phenylbutyrate | Guanidine hydrochloride | Hydroxychloroquine | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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